Most head and neck cancers are derived from the mucosal epithelium in the oral cavity,
pharynx and larynx and are known collectively as head and neck squamous cell carcinoma …

Tumorigenesis begins long before the growth of a clinically detectable lesion and, indeed,
even before any of the usual morphological correlates of pre-malignancy are recognizable …

Abstract Purpose: Circulating tumor DNA (ctDNA) enables personalized treatment strategies
in oncology by providing a noninvasive source of clinical biomarkers. In patients with low …

Head and neck cancer is a common and aggressive malignancy with a high morbidity and
mortality profile. Although the large majority of cases resemble head and neck squamous …

The stochastic simulation algorithm commonly known as Gillespie's algorithm (originally
derived for modelling well-mixed systems of chemical reactions) is now used ubiquitously in …

Cumulative evidence indicates that a significant proportion of cancer evolution may occur
before the development of histological abnormalities. While recent improvements in DNA …

Genomic sequencing projects unraveled the mutational landscape of head and neck
squamous cell carcinoma (HNSCC) and provided a comprehensive catalog of somatic …

Introduction: There is still no general method for discriminating between benign and
malignant leukoplakia and identifying vocal fold leukoplakia. Objective: To evaluate the …

Introduction Oral epithelial dysplasia is considered a potential histologic precursor of
subsequent squamous cell cancer. As standard clinical practice, pathologists grade …

We have previously demonstrated that PD-1 blockade decreased the incidence of high-
grade dysplasia in a carcinogen-induced murine model of oral squamous cell carcinoma …