The field of vascular biology has gained enormous insight from the use of Cre and inducible
Cre mouse models to temporally and spatially manipulate gene expression within the …

Cre/LoxP has broad utility for studying the function, development, and oncogenic
transformation of pancreatic cells in mice. Here we provide an overview of the Cre driver …

Global DNA demethylation in humans is a fundamental process that occurs in pre-
implantation embryos and reversion to naive ground state pluripotent stem cells (PSCs) …

The establishment of the anteroposterior (AP) axis is a crucial step during animal embryo
development. In mammals, genetic studies have shown that this process relies on signals …

During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the
three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo …

Adult-repopulating hematopoietic stem cells (HSCs) emerge in low numbers in the
midgestation mouse embryo from a subset of arterial endothelium, through an endothelial-to …

Summary Canonical Wnt and Nodal signaling are both required for induction of the primitive
streak (PS), which guides organization of the early embryo. The Wnt effector β-catenin is …

Although it is well recognized that haematopoietic stem cells (HSCs) develop from a
specialized population of endothelial cells known as haemogenic endothelium, the …

Long non-coding RNAs (lncRNAs) regulate diverse biological processes, including cell
lineage specification. Here, we report transcriptome profiling of human endoderm and …

A network of co-hepato/pancreatic stem/progenitors exists in pigs and humans in Brunner's
Glands in the submucosa of the duodenum, in peribiliary glands (PBGs) of intrahepatic and …