Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles
in health and disease. Recent technologies have uncovered the functional heterogeneity of …

Cytokines are key messengers by which immune cells communicate, and they drive many
physiological processes, including immune and inflammatory responses. Early discoveries …

Multimodal astrocyte–neuron communications govern brain circuitry assembly and function.
For example, through rapid glutamate release, astrocytes can control excitability, plasticity …

Astrocytes control multiple processes in the nervous system in health and disease. It is now
clear that specific astrocyte subsets or activation states are associated with specific genomic …

Currently, there is no disease-modifying treatment available for Alzheimer's and Parkinson's
disease (AD and PD) and that includes the highly controversial approval of the Aβ-targeting …

The involvement of central and peripheral inflammation in the pathogenesis and prognosis
of major depressive disorder (MDD) has been demonstrated. The increase of pro …

Glutamate is one of the most prevalent neurotransmitters released by excitatory neurons in
the central nervous system (CNS); however, residual glutamate in the extracellular space is …

Microglia-astrocyte crosstalk has recently been at the forefront of glial research. Emerging
evidence illustrates that microglia-and astrocyte-derived signals are the functional …

Neuroinflammation in the central nervous system (CNS) is an important subject of
neuroimmunological research. Emerging evidence suggests that neuroinflammation is a key …

Septic-associated encephalopathy (SAE) is a key manifestation of sepsis, ranging from
delirium to coma and occurring in up to 70% of patients admitted to the ICU. SAE is …