The carbamate group is a key structural motif in many approved drugs and prodrugs. There
is an increasing use of carbamates in medicinal chemistry and many derivatives are …

HIV-1 protease inhibitors continue to play an important role in the treatment of HIV/AIDS,
transforming this deadly ailment into a more manageable chronic infection. Over the years …

Combination drugs are an important class of US FDA approved pharmaceuticals. These
drugs have been on a continuous growth trajectory since the first combination drugs were …

Abstract Structure‐based ligand design in medicinal chemistry and crop protection relies on
the identification and quantification of weak noncovalent interactions and understanding the …

J. Neurochem.(2012) 120 (Suppl. 1), 71–83. Abstract β‐Secretase (memapsin 2; BACE‐1) is
the first protease in the processing of amyloid precursor protein leading to the production of …

Alzheimer's disease (AD) is a fatal progressive neurodegenerative disorder characterized by
increasing loss in memory, cognition, and function of daily living. Among the many …

Abstract The effects of Naphthol Yellow S (NYS) on the structure and activity of pepsin were
carried out using ultraviolet–visible (UV–Vis) spectroscopy, intrinsic fluorescence …

Aspartic proteases are a relatively small group of proteolytic enzymes that are active in
acidic environments and are found across all forms of life. Certain microorganisms secrete …

The evolution of drug resistance is one of the most fundamental problems in medicine. In
HIV/AIDS, the rapid emergence of drug‐resistant HIV‐1 variants is a major obstacle to …

Design, synthesis, and evaluation of a new class of exceptionally potent HIV-1 protease
inhibitors are reported. Inhibitor 5 displayed superior antiviral activity and drug-resistance …