Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

The combination of computational models and biophysical simulations can help to interpret
an array of experimental data and contribute to the understanding, diagnosis and treatment …

A multicellular ventricular fiber model was used to determine mechanisms of slowed
conduction and conduction failure during acute ischemia. We simulated the three major …

Acute myocardial ischemia is one of the main causes of sudden cardiac death. The
mechanisms have been investigated primarily in experimental and computational studies …

Acute myocardial ischemia induces hyperkalemia (accumulation of extracellular potassium),
a major perpetrator of lethal reentrant ventricular arrhythmias. Despite considerable …

Myocardial ischemia and infarction are associated with substantially increased morbidity
and mortality among patients with diabetes mellitus. Although many factors contribute to the …

Myocardial ischemia is one of the main causes of sudden cardiac death, with 80% of victims
suffering from coronary heart disease. In acute myocardial ischemia, the obstruction of …

Physical activity is one of the most important determinants of cardiac function. The ability of
the heart to increase delivery of oxygen and metabolic fuels relies on an array of adaptive …

Cardiac rhythms arise from electrical activity generated by precisely timed opening and
closing of ion channels in individual cardiac myocytes. These impulses spread throughout …

Interconnected mechanisms of ischemia and reperfusion (IR) has increased the interest in
IR in vitro experiments using human induced pluripotent stem cell-derived cardiomyocytes …