Background Major variations in medical practice have been documented internationally.
Variations raise questions about the quality, equity, and efficiency of resource allocation and …

Monoclonal antibodies (MAbs) have become a substantial part of many pharmaceutical
company portfolios. However, the development process of MAbs for clinical use is quite …

Background—The outcome of atrial fibrillation patients on warfarin partially depends on
maintaining adequate time in therapeutic International Normalized Ratio range (TTR). Large …

Objective We aimed to describe current characteristics of patients admitted for acute
coronary syndrome (ACS) in Western Europe and to analyse whether international in …

Objective To produce comparable risk‐adjusted outcome rates for an international sample of
hospitals in a collaborative project to share outcomes and learning. Data Sources …

Cost-effectiveness analysis has gained status over the last 15 years as an important tool for
assisting resource allocation decisions in a budget-limited environment such as healthcare …

Objective The purpose of this guidance was to assist in the adaptation of
pharmacoeconomic models originally developed in one country and intended for use in …

Cardiovascular clinical trials are increasingly conducted globally as a means to reduce
costs, expedite timelines, provide broad applicability, and satisfy regulatory authorities …

Background: Based on results of the PLATO (Platelet Inhibition and Patient Outcomes) trial
comparing ticagrelor with clopidogrel therapy, the US Food and Drug Administration …

ARISTIZABAL, Juan Carlos et al. Validación de las escalas de riesgo TIMI y GRACE para el
síndrome coronario agudo en una cohorte contemporánea de pacientes. Acta Med Colomb …