Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen

T Hasegawa, T Oka, HG Son, VS Oliver-García, M Azin… - Cell, 2023 - cell.com
Senescent cell accumulation has been implicated in the pathogenesis of aging-associated
diseases, including cancer. The mechanism that prevents the accumulation of senescent …

Immune-checkpoint expression in antigen-presenting cells (APCs) of cytomegaloviruses infection after transplantation: as a diagnostic biomarker

PS Aghbash, R Rasizadeh, V Arefi, JS Nahand… - Archives of …, 2023 - Springer
Cytomegalovirus (CMV), a member of the Herpesviridae family, mostly causes only slight
feverish symptoms or can be asymptomatic in immunocompetent individuals. However, it is …

[HTML][HTML] Evaluating prognostic value of biliary stone in intrahepatic cholangiocarcinoma by propensity score matching analysis

Y Wang, A Huang, D Guo, J Wang, F Chen… - Journal of …, 2023 - ncbi.nlm.nih.gov
Methods: Clinical data of 985 ICC patients were classified into no BTS group and BTS group-
subgrouped into hepatolithiasis (HL) and non-hepatolithiasis (NHL) group. Propensity score …

HCMV carriage in the elderly diminishes anti-viral functionality of the adaptive immune response resulting in virus replication at peripheral sites

EL Davies, M Noor, EY Lim, CJ Houldcroft… - Frontiers in …, 2022 - frontiersin.org
Human cytomegalovirus (HCMV) infection and periodic reactivation is, generally, well
controlled by adaptative immune responses in the healthy. In older people, overt HCMV …

microRNA, a subtle indicator of human cytomegalovirus against host immune cells

M Yu, Y **, S Zhang, J Xu, J Zhang - Vaccines, 2022 - mdpi.com
Human cytomegalovirus (HCMV) is a double-stranded DNA virus that belongs to the β-
herpesvirus family and infects 40–90% of the adult population worldwide. HCMV infection is …

[HTML][HTML] PD-1 deficiency impairs eosinophil recruitment to tissue during Trichinella spiralis infection

Y Liu, S Zhao, S Du, Y Zhang, Y Yu, B Zhan, J Hao… - Cell reports, 2024 - cell.com
Blockade of programmed cell death 1 (PD-1) is considered a promising strategy for
controlling pathogen infection by enhancing host immune cell function. Eosinophils, which …

Effect of cytomegalovirus on the immune system: implications for aging and mental health

BN Ford, J Savitz - Microorganisms and Mental Health, 2022 - Springer
Human cytomegalovirus (HCMV) is a major modulator of the immune system leading to long-
term changes in T-lymphocytes, macrophages, and natural killer (NK) cells among others …

Enhanced programmed cell death protein 1/programmed cell death ligand 1 expression induced by severe influenza a virus infection impairs host's antiviral response

H Ou, L Chen, H Wu - Viral Immunology, 2022 - liebertpub.com
Emerging research shows that the Programmed Cell Death Protein 1/Programmed Cell
Death Ligand 1 (PD-1/PD-L1) pathway modulates the antiviral response following influenza …

Glatiramer Acetate Complexed with CpG as Intratumoral Immunotherapy in Combination with Anti-PD-1

A Huang, C Groer, R Lu, ML Forrest… - Molecular …, 2022 - ACS Publications
CpG oligodeoxynucleotides are toll-like receptor 9 agonists capable of inducing potent pro-
inflammatory immune responses. Although CpG oligodeoxynucleotides have shown …

Potency assessment of IFNγ-producing SARS-CoV-2-specific T cells from COVID-19 convalescent subjects

R Gil-Bescós, A Ostiz, S Zalba, I Tamayo… - Life Science …, 2023 - life-science-alliance.org
The development of new therapies for COVID-19 high-risk patients remains necessary to
prevent additional deaths. Here, we studied the phenotypical and functional characteristics …