Pichia pastoris has been recognized as one of the most industrially important hosts for
heterologous protein production. Despite its high protein productivity, the optimization of P …

Highlights•Challenges the biopharmaceutical industry is facing at the moment.•Summary of
data science challenges due to biopharma particularities.•Review of today's data science …

Abstract Model-based methods are increasingly used in all areas of biopharmaceutical
process technology. They can be applied in the field of experimental design, process …

Microalgae are well-known photosynthetic microorganisms used as cell factories for the
production of relevant biotechnological compounds. Despite the outstanding characteristics …

Therapeutic monoclonal antibodies are mainly produced in mammalian cells to date.
However, unglycosylated antibody fragments can also be produced in the bacterium …

Biotherapeutics, such as those derived from monoclonal antibodies (mAbs), are industrially
produced in controlled multiunit operation bioprocesses. Each unit operation contributes to …

In this work we present a soft sensor to accurately estimate the yield coefficient YX/S and the
substrate uptake capacity q S max in a cultivation process using offgas measurements and a …

Three distinctive start-up strategies of biogas reactors fed with source-sorted organic fraction
of municipal solid waste were investigated to reveal the most reliable procedure for rapid …

This mini‐review discusses how soft sensors can contribute to accomplish FDA's process
analytical technology (PAT) ambitions in the manufacture of bio‐therapeutics. Focus is on …

Upstream bioprocess characterization and optimization are time and resource‐intensive
tasks. Regularly in the biopharmaceutical industry, statistical design of experiments (DoE) in …