Members of the polo-like kinase (PLK) family are crucial regulators of cell cycle progression,
centriole duplication, mitosis, cytokinesis and the DNA damage response. PLKs undergo …

The polo-like kinase 1 (PLK1) acts in concert with cyclin-dependent kinase 1–cyclin B1 and
Aurora kinases to orchestrate a wide range of critical cell cycle events. Because PLK1 has …

Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these …

Mammalian polo-like kinases (Plks) are characterized by the presence of an N-terminal
protein kinase domain and a C-terminal polo-box domain (PBD) involved in substrate …

The basic biology of the cell division cycle and its control by protein kinases was originally
studied through genetic and biochemical studies in yeast and other model organisms. The …

Polo-like kinases (Plks) are a family of serine-threonine kinases that regulate multiple
intracellular processes including DNA replication, mitosis, and stress response. Plk1, the …

Inhibitors of mitotic protein kinases are currently being developed as non-neurotoxic
alternatives of microtubule-targeting agents (taxanes, vinca alkaloids) which provide a …

During cell division, duplicated genetic material is separated into two distinct daughter cells.
This process is essential for initial tissue formation during development and to maintain …

Abstract The Polo Kinase is a central regulator of cell division required for several events of
mitosis and cytokinesis. In addition to a kinase domain (KD), Polo-like kinases (Plks) …

Polo-like kinases (Plks) are characterized by the presence of a specific domain, known as
the polo box (PBD), involved in protein-protein interactions. Plk1 to Plk4 are involved in …