Complex interactions between the immune system and tumor cells exist throughout the
initiation and development of cancer. Although the immune system eliminates malignantly …

Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

The tumor microenvironment restrains conventional T cell (Tconv) activation while facilitating
the expansion of Tregs. Here we showed that Tregs' advantage in the tumor milieu relies on …

Despite past extensive studies, the mechanisms underlying pulmonary fibrosis (PF) still
remain poorly understood. Here, we demonstrated that lungs originating from different types …

The cytokine storm has captured the attention of the public and the scientific community
alike, and while the general notion of an excessive or uncontrolled release of …

Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia
associated with the metabolic syndrome and type 2 diabetes. In spite of being effective in …

A hallmark of obesity is chronic low‐grade inflammation, which plays a major role in the
process of atherosclerotic cardiovascular disease (ACVD). Gut microbiota is one of the …

Upon antigen stimulation, the bioenergetic demands of T cells increase dramatically over
the resting state. Although a role for the metabolic switch to glycolysis has been suggested …

To the Editor—Human organoids hold tremendous potential for biomedical applications 1–3
(Fig. 1a, b). These three-dimensional structures of cultured cells recapitulate important …

Omega‐6 (n‐6) polyunsaturated fatty acids (PUFA)(eg, arachidonic acid (AA)) and omega‐3
(n‐3) PUFA (eg, eicosapentaenoic acid (EPA)) are precursors to potent lipid mediator …