How do stem cells find their way home?
T Lapidot, A Dar, O Kollet - Blood, 2005 - ashpublications.org
Migration of hematopoietic stem cells through the blood, across the endothelial vasculature
to different organs and to their bone marrow (BM) niches, requires active navigation, a …
to different organs and to their bone marrow (BM) niches, requires active navigation, a …
CXCR4–SDF-1 signalling, locomotion, chemotaxis and adhesion
Chemokines, small pro-inflammatory chemoattractant cytokines, that bind to specific G-
protein-coupled seven-span transmembrane receptors present on plasma membranes of …
protein-coupled seven-span transmembrane receptors present on plasma membranes of …
Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist
Stromal cell-derived factor 1 (SDF1/CXCL12) and its cognate receptor, CXCR4, play key
regulatory roles in CD34+ cell trafficking. We investigated whether AMD3100, a selective …
regulatory roles in CD34+ cell trafficking. We investigated whether AMD3100, a selective …
[HTML][HTML] Current understanding of stem cell mobilization: the roles of chemokines, proteolytic enzymes, adhesion molecules, cytokines, and stromal cells
T Lapidot, I Petit - Experimental hematology, 2002 - Elsevier
Mobilization of hematopoietic stem and progenitor cells from the bone marrow into the
circulation by repetitive, daily stimulations with G-CSF alone, or in combination with …
circulation by repetitive, daily stimulations with G-CSF alone, or in combination with …
Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF‐1–CXCR4 axis
The α‐chemokine stromal‐derived factor (SDF)‐1 and the G‐protein–coupled seven‐span
transmembrane receptor CXCR4 axis regulates the trafficking of various cell types. In this …
transmembrane receptor CXCR4 axis regulates the trafficking of various cell types. In this …
The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and …
T Lapidot, O Kollet - Leukemia, 2002 - nature.com
Hematopoietic stem cells are identified based on their functional ability to migrate via the
blood circulation of transplanted recipients, to home to the host bone marrow and to durably …
blood circulation of transplanted recipients, to home to the host bone marrow and to durably …
[HTML][HTML] Regulation of CXCR4 expression in human mesenchymal stem cells by cytokine treatment: role in homing efficiency in NOD/SCID mice
M Shi, J Li, L Liao, B Chen, B Li, L Chen, H Jia… - …, 2007 - haematologica.org
Abstract Background and Objectives The use of mesenchymal stem cells (MSC) for cell
therapy relies on the capacity of these cells to home and engraft long-term into the …
therapy relies on the capacity of these cells to home and engraft long-term into the …
Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment
A Janowska-Wieczorek, M Majka… - Blood, The Journal …, 2001 - ashpublications.org
Because human CD34+ and murine Sca-1+ hematopoietic stem–progenitor cells (HSPCs)
express platelet-binding sialomucin P-selectin (CD162) and integrin Mac-1 (CD11b–CD18) …
express platelet-binding sialomucin P-selectin (CD162) and integrin Mac-1 (CD11b–CD18) …
Adult stem cell plasticity
R Poulsom, MR Alison, SJ Forbes… - The Journal of …, 2002 - Wiley Online Library
Observations made in the last few years support the existence of pathways, in adult humans
and rodents, that allow adult stem cells to be surprisingly flexible in their differentiation …
and rodents, that allow adult stem cells to be surprisingly flexible in their differentiation …
Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte–colony‐stimulating factor by single …
BACKGROUND: AMD3100, a selective antagonist of CXCR4, rapidly mobilizes CD34+
hematopoietic progenitor cells (HPCs) from marrow to peripheral blood with minimal side …
hematopoietic progenitor cells (HPCs) from marrow to peripheral blood with minimal side …