[HTML][HTML] Glucagon-like peptide 1 (GLP-1)
TD Müller, B Finan, SR Bloom, D D'Alessio… - Molecular …, 2019 - Elsevier
Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …
The discovery and development of liraglutide and semaglutide
LB Knudsen, J Lau - Frontiers in endocrinology, 2019 - frontiersin.org
The discovery of glucagon-like peptide-1 (GLP-1), an incretin hormone with important effects
on glycemic control and body weight regulation, led to efforts to extend its half-life and make …
on glycemic control and body weight regulation, led to efforts to extend its half-life and make …
Dissociable hindbrain GLP1R circuits for satiety and aversion
KP Huang, AA Acosta, MY Ghidewon, AD McKnight… - Nature, 2024 - nature.com
The most successful obesity therapeutics, glucagon-like peptide-1 receptor (GLP1R)
agonists, cause aversive responses such as nausea and vomiting,, effects that may …
agonists, cause aversive responses such as nausea and vomiting,, effects that may …
[HTML][HTML] Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist
Tirzepatide (LY3298176) is a dual GIP and GLP-1 receptor agonist under development for
the treatment of type 2 diabetes mellitus (T2DM), obesity, and nonalcoholic steatohepatitis …
the treatment of type 2 diabetes mellitus (T2DM), obesity, and nonalcoholic steatohepatitis …
Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) exert anti-inflammatory effects
relevant to the chronic complications of type 2 diabetes. Although GLP-1RAs attenuate T cell …
relevant to the chronic complications of type 2 diabetes. Although GLP-1RAs attenuate T cell …
[HTML][HTML] Semaglutide lowers body weight in rodents via distributed neural pathways
Semaglutide, a glucagon-like peptide 1 (GLP-1) analog, induces weight loss, lowers
glucose levels, and reduces cardiovascular risk in patients with diabetes. Mechanistic …
glucose levels, and reduces cardiovascular risk in patients with diabetes. Mechanistic …
Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation
Abstract Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …
brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and …
GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans
Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are effective antiobesity
drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We …
drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We …
[HTML][HTML] The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in
the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the …
the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the …
Integrative neurocircuits that control metabolism and food intake
JC Brüning, H Fenselau - Science, 2023 - science.org
Systemic metabolism has to be constantly adjusted to the variance of food intake and even
be prepared for anticipated changes in nutrient availability. Therefore, the brain integrates …
be prepared for anticipated changes in nutrient availability. Therefore, the brain integrates …