Naturally evolved organisms typically have large genomes that enable their survival and
growth under various conditions. However, the complexity of genomes often precludes our …

Algae are diverse organisms with significant biotechnological potential for resource
circularity. Taking inspiration from fermentative microbes, engineering algal genomes holds …

Here, we report the design, construction, and characterization of a tRNA neochromosome, a
designer chromosome that functions as an additional, de novo counterpart to the native …

Site-specific recombinases such as the Cre-LoxP system are routinely used for genome
engineering in both prokaryotes and eukaryotes. Importantly, recombinases complement the …

Synthetic biology confers new functions to hosts by introducing exogenous genetic
elements, yet rebuilding complex traits that are based on large-scale genetic information …

Human enterprises through the solar system will entail long-duration voyages and habitation
creating challenges in maintaining healthy diets. We discuss consolidating multiple sensory …

De novo chromosome synthesis is costly and time-consuming, limiting its use in research
and biotechnology. Building synthetic chromosomes from natural components is an …

The history of yeast Saccharomyces cerevisiae, aka brewer's or baker's yeast, is intertwined
with our own. Initially domesticated 8,000 years ago to provide sustenance to our ancestors …

Whether synthetic genomes can power life has attracted broad interest in the synthetic
biology field. Here, we report de novo synthesis of the largest eukaryotic chromosome thus …

The domestication of vines started in Asia 11,000 years ago, although it was not until the
19th century that oenology was established as a scientific discipline thanks to the research …