Most of the leading causes of death, such as cardiovascular diseases, cancer, dementia,
neurodegenerative diseases, and many more, are associated with sterile inflammation …

Single-cell approaches have shone a spotlight on discrete context-specific tissue
macrophage states, deconstructed to their most minute details. Machine-learning (ML) …

Bacterial infection causes lung inflammation and recruitment of several inflammatory factors
that may result in acute lung injury (ALI). During bacterial infection, reactive oxygen species …

The innate immune system initiates early response to infection by sensing molecular
patterns of infection through pattern-recognition receptors (PRRs). Previous work on PRR …

The balance between pro-and anti-inflammatory immune system responses is crucial to
preventing complex diseases like cancer. Macrophages are essential immune cells that …

Innate immune memory (also termed trained immunity) is defined in part by its ability to cross-
protect against heterologous pathogens, and can be generated by many different stimuli …

Many pathogens are hard to eradicate, even in the absence of genetically detectable
antimicrobial resistance mechanisms and despite proven antibiotic susceptibility. The …