More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis

A Frey, LP Lunding, JC Ehlers, M Weckmann… - Frontiers in …, 2020 - frontiersin.org
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …

Respiratory epithelial cells orchestrate pulmonary innate immunity

JA Whitsett, T Alenghat - Nature immunology, 2015 - nature.com
The epithelial surfaces of the lungs are in direct contact with the environment and are
subjected to dynamic physical forces as airway tubes and alveoli are stretched and …

Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses

R Maroto, Y Zhao, M Jamaluddin… - Journal of …, 2017 - Taylor & Francis
Background: Extracellular vesicles contain biological molecules specified by cell-type of
origin and modified by microenvironmental changes. To conduct reproducible studies on …

[HTML][HTML] Bifurcation of signalling in human innate immune pathways to NF-kB and IRF family activation

A Kusiak, G Brady - Biochemical Pharmacology, 2022 - Elsevier
The human innate immune response can be activated through a wide range of stimuli. This
multi-faceted system can be triggered by a range of immunostimulants including pathogen …

NF-κB and IRF pathways: cross-regulation on target genes promoter level

M Iwanaszko, M Kimmel - BMC genomics, 2015 - Springer
Abstract Background The NF-κB and IRF transcription factor families are major players in
inflammation and antiviral response and act as two major effectors of the innate immune …

Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways

M Czerkies, Z Korwek, W Prus, M Kochańczyk… - Nature …, 2018 - nature.com
The innate immune system processes pathogen-induced signals into cell fate decisions.
How information is turned to decision remains unknown. By combining stochastic …

BRD4 couples NF-κB/RelA with airway inflammation and the IRF-RIG-I amplification loop in respiratory syncytial virus infection

B Tian, J Yang, Y Zhao, T Ivanciuc, H Sun… - Journal of …, 2017 - journals.asm.org
The airway mucosa expresses protective interferon (IFN) and inflammatory cytokines in
response to respiratory syncytial virus (RSV) infection. In this study, we examine the role of …

Systematic analysis of cell-type differences in the epithelial secretome reveals insights into the pathogenesis of respiratory syncytial virus–induced lower respiratory …

Y Zhao, M Jamaluddin, Y Zhang, H Sun… - The Journal of …, 2017 - journals.aai.org
Lower respiratory tract infections from respiratory syncytial virus (RSV) are due, in part, to
secreted signals from lower airway cells that modify the immune response and trigger airway …

NF-κB mediates mesenchymal transition, remodeling, and pulmonary fibrosis in response to chronic inflammation by viral RNA patterns

B Tian, I Patrikeev, L Ochoa, G Vargas… - American journal of …, 2017 - atsjournals.org
Airway remodeling is resultant of a complex multicellular response associated with a
progressive decline of pulmonary function in patients with chronic airway disease. Here …

[HTML][HTML] African swine fever virus CD2v protein induces β-interferon expression and apoptosis in swine peripheral blood mononuclear cells

S Chaulagain, GA Delhon, S Khatiwada, DL Rock - Viruses, 2021 - mdpi.com
African swine fever (ASF) is a hemorrhagic disease of swine characterized by massive
lymphocyte depletion in lymphoid tissues due to the apoptosis of B and T cells, a process …