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Intracellular calcium release channels: an update
Ryanodine receptors (RyRs) and inositol 1, 4, 5‐trisphosphate receptors (IP3Rs) are
calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we …
calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we …
[HTML][HTML] NADPH oxidases and oxidative stress in the pathogenesis of atrial fibrillation
Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and its prevalence
increases with age. The irregular and rapid contraction of the atria can lead to ineffective …
increases with age. The irregular and rapid contraction of the atria can lead to ineffective …
SGLT2 inhibition via empagliflozin improves endothelial function and reduces mitochondrial oxidative stress: insights from frail hypertensive and diabetic patients
Background: Frailty is a multidimensional condition often diagnosed in older adults with
hypertension and diabetes, and both these conditions are associated with endothelial …
hypertension and diabetes, and both these conditions are associated with endothelial …
Mitochondrial calcium overload is a key determinant in heart failure
Calcium (Ca2+) released from the sarcoplasmic reticulum (SR) is crucial for excitation–
contraction (E–C) coupling. Mitochondria, the major source of energy, in the form of ATP …
contraction (E–C) coupling. Mitochondria, the major source of energy, in the form of ATP …
[HTML][HTML] miR-98 regulates TMPRSS2 expression in human endothelial cells: key implications for COVID-19
The two main co-factors needed by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) to enter human cells are angiotensin-converting enzyme 2 (ACE2) and …
(SARS-CoV-2) to enter human cells are angiotensin-converting enzyme 2 (ACE2) and …
Mitochondrial oxidative stress promotes atrial fibrillation
Oxidative stress has been suggested to play a role in the pathogenesis of atrial fibrillation
(AF). Indeed, the prevalence of AF increases with age as does oxidative stress. However …
(AF). Indeed, the prevalence of AF increases with age as does oxidative stress. However …
Calcium release channel RyR2 regulates insulin release and glucose homeostasis
The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic
reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In …
reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In …
Irisin protects against endothelial injury and ameliorates atherosclerosis in apolipoprotein E-Null diabetic mice
J Lu, G **ang, M Liu, W Mei, L **ang, J Dong - Atherosclerosis, 2015 - Elsevier
Objective The circulating irisin increases energy expenditure and improves insulin
resistance in mice and humans. The improvement of insulin resistance ameliorates …
resistance in mice and humans. The improvement of insulin resistance ameliorates …
Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging
Calcium (Ca2+) release from intracellular stores controls numerous cellular processes,
including cardiac and skeletal muscle contraction, synaptic transmission and metabolism …
including cardiac and skeletal muscle contraction, synaptic transmission and metabolism …
miR-181c targets Parkin and SMAD7 in human cardiac fibroblasts: Validation of differential microRNA expression in patients with diabetes and heart failure with …
Background Cardiac fibrosis represents a key element in the pathophysiology of heart
failure with preserved ejection fraction (HFpEF), a condition highly prevalent amongst …
failure with preserved ejection fraction (HFpEF), a condition highly prevalent amongst …