Microfluidic trends in drug screening and drug delivery

J Feng, J Neuzil, A Manz, C Iliescu, P Neuzil - TrAC Trends in Analytical …, 2023 - Elsevier
The low probability of a drug candidate's clinical success, the time consumed and the high
cost of bringing a drug from concept to market emphasizes the need for new approaches to …

Quantitative or digital PCR? A comparative analysis for choosing the optimal one for biosensing applications

H Zhang, L Cao, J Brodsky, I Gablech, F Xu, Z Li… - TrAC Trends in …, 2024 - Elsevier
This paper offers an exhaustive comparison of quantitative PCR (qPCR) and digital PCR
(dPCR) technologies, focusing on their critical roles in molecular diagnostics, ranging from …

Rapid Detection of Uropathogens Using an Integrated Multiplex Digital Nucleic Acid Detection Assay Powered by a Digital-to-Droplet Microfluidic Device

Y **e, Z Chen, D Cai, D Huang, E Huang… - Analytical …, 2024 - ACS Publications
The digital nucleic acid detection assay features the capability of absolute quantitation
without the need for calibration, thereby facilitating the rapid identification of pathogens …

Supercritical fluid technology: A game-changer for biomacromolecular nanomedicine preparation and biomedical application

Y Zheng, Y Huang, J Luo, X Peng, X Gui, G Liu… - Chinese Chemical …, 2024 - Elsevier
Biomacromolecules are attractive in biomedical applications as therapeutic agents and
potential drug carriers due to their natural active components, good biocompatibility, and …

based loop mediated isothermal amplification (Lamp) platforms: integrating the versatility of paper microfluidics with accuracy of nucleic acid amplification tests

D Das, M Masetty, A Priye - Chemosensors, 2023 - mdpi.com
Paper-based diagnostics offer a promising alternative to traditional diagnostic methods for
point-of-care use due to their low cost, ease of use, portability, rapid results, versatility, and …

Establishment of Digital PCR Method and Reference Material for Adenoviruses 40 and 41

G Chen, H Li, Y Gao, H Zhao, J Yang… - … Pathogens and Disease, 2023 - liebertpub.com
Coinfection with human adenovirus (HAdV) and SARS-CoV-2 has been associated with
acute hepatitis in children with unknown etiology. Similar cases have been reported in many …

PhageBox: An Open Source Digital Microfluidic Extension With Applications for Phage Discovery

D Albin, L Buecherl, E Kochavi… - IEEE Transactions …, 2023 - ieeexplore.ieee.org
Objective: Recent advancements demonstrate the significant role of digital microfluidics in
automating laboratory work with DNA and on-site viral testing. However, since commercially …

Evaluation of droplet digital PCR by detecting cell-free DNA in pleural effusion for the diagnosis of tuberculous pleurisy: a multicenter cohort study

F Xu, W Du, C Li, Y Li, Z Li, W Han, H Li, J Liang… - Clinical Microbiology …, 2024 - Elsevier
Objectives Tuberculous pleurisy is one of the most common extra-pulmonary tuberculosis,
but the sensitivity of conventional mycobacterial culture (Culture) or Xpert MTB/RIF assay …

The Cross-Talk of Non-coding RNAs and Inflammation in Human Cancer

J Li, X Lei, X Yang - Current Pharmaceutical Biotechnology, 2025 - ingentaconnect.com
Despite advanced clinical treatment, the mortality rate of cancer patients is high. Recent
studies have linked the development of cancer to inflammation. Many cancers are …