The cell biology of asthma
DJ Erle, D Sheppard - Journal of Cell Biology, 2014 - rupress.org
The clinical manifestations of asthma are caused by obstruction of the conducting airways of
the lung. Two airway cell types are critical for asthma pathogenesis: epithelial cells and …
the lung. Two airway cell types are critical for asthma pathogenesis: epithelial cells and …
Breathing exercises for adults with asthma
Background Breathing exercises have been widely used worldwide as a non‐
pharmacological therapy to treat people with asthma. Breathing exercises aim to control the …
pharmacological therapy to treat people with asthma. Breathing exercises aim to control the …
Effect of tezepelumab on airway inflammatory cells, remodelling, and hyperresponsiveness in patients with moderate-to-severe uncontrolled asthma (CASCADE): a …
Background Tezepelumab is a human monoclonal antibody that blocks the activity of thymic
stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine. In phase 2b and 3 studies …
stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine. In phase 2b and 3 studies …
Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: clinical and histopathologic correlations
M Pretolani, A Bergqvist, G Thabut, MC Dombret… - Journal of Allergy and …, 2017 - Elsevier
Background The effectiveness of bronchial thermoplasty (BT) has been reported in patients
with severe asthma, yet its effect on different bronchial structures remains unknown …
with severe asthma, yet its effect on different bronchial structures remains unknown …
The Saudi Initiative for Asthma-2021 Update: Guidelines for the diagnosis and management of asthma in adults and children
Abstract The Saudi Initiative for Asthma 2021 (SINA-2021) is the fifth version of asthma
guidelines for the diagnosis and management of asthma for adults and children, which is …
guidelines for the diagnosis and management of asthma for adults and children, which is …
[HTML][HTML] Transforming growth factor β and severe asthma: a perfect storm
M Al-Alawi, T Hassan, SH Chotirmall - Respiratory medicine, 2014 - Elsevier
Asthma is a chronic inflammatory airway disease involving complex interplay between
resident and infiltrative cells, which in turn are regulated by a wide range of host mediators …
resident and infiltrative cells, which in turn are regulated by a wide range of host mediators …
[HTML][HTML] Biological clustering supports both “Dutch” and “British” hypotheses of asthma and chronic obstructive pulmonary disease
Background Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous
diseases. Objective We sought to determine, in terms of their sputum cellular and mediator …
diseases. Objective We sought to determine, in terms of their sputum cellular and mediator …
Biologics for severe asthma—Which, when and why?
Asthma is a common chronic inflammatory condition of the airways that affects about 350
million people globally. In 5%–10% of individuals, it is severe, with considerable morbidity …
million people globally. In 5%–10% of individuals, it is severe, with considerable morbidity …
Statistical cluster analysis of the British Thoracic Society Severe refractory Asthma Registry: clinical outcomes and phenotype stability
Background Severe refractory asthma is a heterogeneous disease. We sought to determine
statistical clusters from the British Thoracic Society Severe refractory Asthma Registry and to …
statistical clusters from the British Thoracic Society Severe refractory Asthma Registry and to …
Inspiratory muscle training for asthma
IS Silva, GAF Fregonezi, FAL Dias… - Cochrane Database …, 2013 - cochranelibrary.com
Background In some people with asthma, expiratory airflow limitation, premature closure of
small airways, activity of inspiratory muscles at the end of expiration and reduced pulmonary …
small airways, activity of inspiratory muscles at the end of expiration and reduced pulmonary …