Since the year 2000, historic reductions in malaria incidence and mortality have been driven
by the widespread distribution of bed nets, drugs, and insecticides for the prevention and …

Background Deletion of pfhrp2 and/or pfhrp3 genes cause false negatives in malaria rapid
diagnostic test (RDT) and threating malaria control strategies. This systematic review aims to …

In Africa, most rapid diagnostic tests (RDTs) for falciparum malaria recognize histidine-rich
protein 2 antigen. Plasmodium falciparum parasites lacking histidine-rich protein 2 (pfhrp2) …

Each year, WHO's World malaria report offers in-depth information on the latest trends in
malaria control and elimination at global, regional and country levels. The report highlights …

Plasmodium falciparum with the histidine rich protein 2 gene (pfhrp2) deleted from its
genome can escape diagnosis by HRP2-based rapid diagnostic tests (HRP2-RDTs). The …

Histidine-rich protein 2 (HRP2)–based rapid diagnostic tests detect Plasmodium falciparum
malaria and are used throughout sub-Saharan Africa. However, deletions in the pfhrp2 and …

Deletions of pfhrp2 and paralogue pfhrp3 (pfhrp2/3) genes threaten Plasmodium falciparum
diagnosis by rapid diagnostic test. We examined 1,002 samples from suspected malaria …

Molecular surveillance for malaria has great potential to support national malaria control
programs (NMCPs). To bridge the gap between research and implementation, several …

The majority of Plasmodium falciparum malaria diagnoses in Africa are made using rapid
diagnostic tests (RDTs) that detect histidine-rich protein 2. Increasing reports of false …

Eritrea was the first African country to complete a nationwide switch in 2016 away from
HRP2-based RDTs due to high rates of false-negative RDT results caused by Plasmodium …