Molecular mechanisms of oxidative stress in asthma
C Michaeloudes, H Abubakar-Waziri, R Lakhdar… - Molecular aspects of …, 2022 - Elsevier
The lungs are exposed to reactive oxygen species oxygen (ROS) produced as a result of
inhalation of oxygen, as well as smoke and other air pollutants. Cell metabolism and the …
inhalation of oxygen, as well as smoke and other air pollutants. Cell metabolism and the …
Airway remodeling in asthma
Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …
Oxidative stress and inflammation in acute and chronic lung injuries
FS Bezerra, M Lanzetti, RT Nesi, AC Nagato, CP Silva… - Antioxidants, 2023 - mdpi.com
Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung
injury can affect several components of the respiratory system, including the airways …
injury can affect several components of the respiratory system, including the airways …
Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank
Background Clinical and epidemiologic studies have shown that obesity is associated with
asthma and that these associations differ by asthma subtype. Little is known about the …
asthma and that these associations differ by asthma subtype. Little is known about the …
Airway remodeling in asthma: what really matters
Airway remodeling is generally quite broadly defined as any change in composition,
distribution, thickness, mass or volume and/or number of structural components observed in …
distribution, thickness, mass or volume and/or number of structural components observed in …
'WNT-er is coming': WNT signalling in chronic lung diseases
HA Baarsma, M Königshoff - Thorax, 2017 - thorax.bmj.com
Chronic lung diseases represent a major public health problem with only limited therapeutic
options. An important unmet need is to identify compounds and drugs that target key …
options. An important unmet need is to identify compounds and drugs that target key …
Associations between blood eosinophils and decline in lung function among adults with and without asthma
Eosinophilic inflammation and airway remodelling are characteristic features of asthma, but
the association between them is unclear. We assessed associations between blood …
the association between them is unclear. We assessed associations between blood …
[HTML][HTML] IL-4 and IL-13, not eosinophils, drive type 2 airway inflammation, remodeling and lung function decline
Abstract Rationale Type 2 (T2) asthma is characterized by airflow limitations and elevated
levels of blood and sputum eosinophils, fractional exhaled nitric oxide, IgE, and periostin …
levels of blood and sputum eosinophils, fractional exhaled nitric oxide, IgE, and periostin …
Modeling TH2 responses and airway inflammation to understand fundamental mechanisms regulating the pathogenesis of asthma
In this review, we highlight experiments conducted in our laboratories that have elucidated
functional roles for CD 4+ T‐helper type‐2 lymphocytes (TH 2 cells), their associated …
functional roles for CD 4+ T‐helper type‐2 lymphocytes (TH 2 cells), their associated …
Unmet need in severe, uncontrolled asthma: can anti-TSLP therapy with tezepelumab provide a valuable new treatment option?
Despite treatment with standard-of-care medications, including currently available biologic
therapies, many patients with severe asthma have uncontrolled disease, which is associated …
therapies, many patients with severe asthma have uncontrolled disease, which is associated …