Few studies are available to inform duration of intravenous antibiotics for children and when
it is safe and appropriate to switch to oral antibiotics. We have systematically reviewed …

Background: Previous evidence-based guidelines on the management of intra-abdominal
infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and …

Background Researchers have suggested that antibiotics could cure acute appendicitis. We
assessed the efficacy of amoxicillin plus clavulanic acid by comparison with emergency …

Background The optimal diagnosis and treatment of appendicitis remains controversial. This
systematic review details the evidence and current best practices for the evaluation and …

Background The appropriate duration of postoperative antibiotics for complex appendicitis is
unclear. The increasing global threat of antimicrobial resistance warrants restrictive …

Background: The efficacy of irrigating the peritoneal cavity during appendectomy for
perforated appendicitis has been debated extensively. To date, prospective comparative …

Importance Optimal duration of antibiotic treatment to reduce infectious complications after
an appendectomy for acute complicated appendicitis remains unclear. Objective To …

Importance Complicated appendicitis is a common condition in children that causes
substantial morbidity. Significant variation in practice exists within and between centers. We …

Welcome to the 29th edition of Nelson's Pediatric Antimicrobial Therapy, the third edition
written during the COVID-19 pandemic, which continues to significantly affect our lives and …

Background For decades, urgent operation has been considered the only appropriate
management of acute appendicitis in children. The purpose of this study was to investigate …