Optimal control of a nonlinear fed-batch fermentation process using model predictive approach

A Ashoori, B Moshiri, A Khaki-Sedigh… - Journal of Process …, 2009 - Elsevier
Bioprocesses are involved in producing different pharmaceutical products. Complicated
dynamics, nonlinearity and non-stationarity make controlling them a very delicate task. The …

Automatic control of bioprocesses

M Stanke, B Hitzmann - … Monitoring, Modelling and Control of Bioprocesses, 2013 - Springer
In this chapter, different approaches for open-loop and closed-loop control applied in
bioprocess automation are discussed. Although in recent years many contributions dealing …

Monitoring and control of bioreactor: Basic concepts and recent advances

J Gomes, V Chopda, AS Rathore - … technology for production of …, 2018 - Wiley Online Library
Bioreactors (fermenters) are the key unit operation in biopharmaceutical, brewing,
biochemical, biofuel, and waste treatment processes. The need for monitoring, control, and …

Macroscopic modelling of overflow metabolism and model based optimization of hybridoma cell fed-batch cultures

Z Amribt, H Niu, P Bogaerts - Biochemical engineering journal, 2013 - Elsevier
A macroscopic model that takes into account phenomena of overflow metabolism within
glycolysis and glutaminolysis is proposed to simulate hybridoma HB-58 cell cultures. The …

Robust nonlinear model predictive control of cascade of fermenters with recycle for efficient bioethanol production

P Skupin, P Łaszczyk, EC Goud, R Vooradi… - Computers & Chemical …, 2022 - Elsevier
In this paper, dynamical behavior and control of the continuous ethanol fermentation
process are studied. The process productivity is improved by using two fermenters …

Model predictive control coupled with economic and environmental constraints for optimum algal production

A Juneja, GS Murthy - Bioresource technology, 2018 - Elsevier
Algae production process is a key cost center in production of biofuels/bioproducts from
microalgae. Decline in the growth of algae in outdoor ponds during non-optimal conditions …

[HTML][HTML] Study of advanced control of ethanol production through continuous fermentation

AH Ajbar, E Ali - Journal of King Saud University-Engineering Sciences, 2017 - Elsevier
This paper investigates the control of an experimentally validated model of production of
bioethanol. The analysis of the open loop system revealed that the maximum productivity …

Multivariable control for tracking optimal profiles in a nonlinear fed-batch bioprocess integrated with state estimation

MN Pantano, ME Serrano, MC Fernández… - Industrial & …, 2017 - ACS Publications
This paper aims to solve the problem of tracking optimal profiles for a nonlinear multivariable
fed-batch bioprocess by a simple but efficient closed-loop control technique based on a …

Modeling and optimization of lipid accumulation by Yarrowia lipolytica from glucose under nitrogen depletion conditions

CE Robles‐Rodríguez… - Biotechnology and …, 2018 - Wiley Online Library
Oleaginous yeasts have been seen as a feasible alternative to produce the precursors of
biodiesel due to their capacity to accumulate lipids as triacylglycerol having profiles with …

Optimización de parámetros utilizando los métodos de Monte Carlo y Algoritmos Evolutivos. Aplicación a un controlador de seguimiento de trayectoria en sistemas no …

C Fernández, N Pantano, S Godoy… - … de Automática e …, 2019 - polipapers.upv.es
En este trabajo se propone una estrategia de control en lazo cerrado para el seguimiento
de perfiles óptimos previamente definidos para un bioproceso fed-batch. La mayor ventaja …