Acute myeloid leukemia (AML) represents 80% of adult leukemias and 15–20% of childhood
leukemias. AML are characterized by the presence of 20% blasts or more in the bone …

Evidence accumulated over the past decades shows that the number of identified antisense
transcripts is continuously increasing, promoting them from transcriptional noise to real …

Understanding the complex network that regulates transcription elongation requires the
quantitative analysis of RNA polymerase II (Pol II) activity in a wide variety of regulatory …

RNA polymerase II (Pol2) movement through chromatin and the co-transcriptional
processing and fate of nascent transcripts is coordinated by transcription elongation factors …

In eukaryotes, RNA species originating from pervasive transcription are regulators of various
cellular processes, from the expression of individual genes to the control of cellular …

Plants have developed multiple strategies to sense the external environment and to adapt
growth accordingly. Delay of germination 1 (DOG 1) is a major quantitative trait locus (QTL) …

Antisense transcription is widespread in genomes. Despite large differences in gene size
and architecture, we find that yeast and human genes share a unique, antisense …

Inhibition of transcription caused by DNA damage-impaired RNA polymerase II (Pol II)
elongation conceals a local increase in de novo transcription, slowly progressing from …

Genomes from yeast to humans are subject to pervasive transcription. A single round of
pervasive transcription is sufficient to alter local chromatin conformation, nucleosome …

RNA is accurately entangled in virtually all pathways that maintain cellular homeostasis. To
name but a few, RNA is the “messenger” between DNA encoded information and the …