In 2007, 1179 papers were published that involved the application of optical biosensors.
Reported developments in instrument hardware, assay design, and immobilization …

Best established as components of steroid hormone receptor complexes, it is now clear that
the large molecular weight immunophilins, FKBP52 and FKBP51, play important regulatory …

Imbalanced protein load within cells is a critical aspect for most diseases of aging. In
particular, the accumulation of proteins into neurotoxic aggregates is a common thread for a …

Hsp90 is critical for the regulation and activation of numerous client proteins critical for
diverse functions such as cell growth, differentiation, and reproduction. Cytosolic Hsp90 …

Abstract From 5 to 12 FK506-binding proteins (FKBPs) are encoded in the genomes of
disparate marine organisms, which appeared at the dawn of evolutionary events giving rise …

Heat shock protein 90 (Hsp-90) is a highly conserved essential protein in eukaryotes. Here
we describe the molecular characterisation of hsp-90 from three nematodes, the free-living …

The molecular chaperone Hsp90 has been discovered in the heat-shock response of the
fruit fly more than 30years ago. Today, it is becoming clear that Hsp90 is in the middle of a …

In meiotic prophase I, homologous chromosome pairing is promoted through chromosome
movement mediated by nuclear envelope proteins, microtubules, and dynein. After proper …

Protein kinases are important regulators in cellular signal transduction. As one major type of
Hsp90 client, protein kinases rely on the ATP-dependent molecular chaperone Hsp90 …

We have cloned and expressed the putative Caenorhabditis elegans orthologue for small
glutamine-rich tetratricopeptide repeat-containing protein, now assigned the gene name sgt …