Global burden, distribution and prevention of β-thalassemias and hemoglobin E disorders

R Colah, A Gorakshakar, A Nadkarni - Expert Review of …, 2010 - Taylor & Francis
The β-thalassemias, including the hemoglobin E disorders, are not only common in the
Mediterranean region, South-East Asia, the Indian subcontinent and the Middle East but …

Early farmers from across Europe directly descended from Neolithic Aegeans

Z Hofmanová, S Kreutzer… - Proceedings of the …, 2016 - National Acad Sciences
Farming and sedentism first appeared in southwestern Asia during the early Holocene and
later spread to neighboring regions, including Europe, along multiple dispersal routes …

Early Neolithic genomes from the eastern Fertile Crescent

F Broushaki, MG Thomas, V Link, S López, L Van Dorp… - Science, 2016 - science.org
We sequenced Early Neolithic genomes from the Zagros region of Iran (eastern Fertile
Crescent), where some of the earliest evidence for farming is found, and identify a previously …

Genetic diseases of hemoglobin: diagnostic methods for elucidating β-thalassemia mutations

S Tuzmen, AN Schechter - Blood reviews, 2001 - Elsevier
INTRODUCTION n the last two decades, a vast array of molecular tools for the diagnosis of
genetic diseases of hemoglobin have been developed that allow definitive identification of …

β-Thalassemia in Turkey: A review of the clinical, epidemiological, molecular, and evolutionary aspects

GO Tadmouri, AN Başak - Hemoglobin, 2001 - Taylor & Francis
INTRODUCTION β-Thalassemia (thal) is one of the most frequent monogenic disorders in
the world and the first disease to be characterized at the DNA level. It is an autosomal …

[PDF][PDF] A national registry of thalassemia in Turkey: demographic and disease characteristics of patients, achievements, and challenges in prevention

Y Aydınok, Y Oymak, B Atabay… - Turkish Journal of …, 2018 - jag.journalagent.com
Objective: The Turkish Society of Pediatric Hematology set up a National Hemoglobinopathy
Registry to demonstrate the demographic and disease characteristics of patients and assess …

Beta thalassemia in 31,734 cases with HBB gene mutations: pathogenic and structural analysis of the common mutations; Iran as the crossroads of the Middle East

N Mahdieh, B Rabbani - Blood reviews, 2016 - Elsevier
Thalassemia is one of the most common single gene disorders worldwide. Nearly 80 to 90
million with minor beta thalassemia and 60–70 thousand affected infants are born annually …

[PDF][PDF] Frequency of haemoglobinopathies at premarital health screening in Dohuk, Iraq: implications for a regional prevention programme

NA Al Allawi, AA Al Dousky - … Health Journal, 16 (4), 381-385, 2010, 2010 - apps.who.int
Beta-thalassaemia major and sickle-cell disease are important health problems in Iraq. To
provide information for a prevention programme, the frequency of haemoglobin disorders …

Premarital screening of beta-thalassemia trait in the province of Denizli, Turkey

A Keskin, T Türk, A Polat, H Koyuncu… - Acta haematologica, 2000 - karger.com
A premarital screening program aiming at reducing the incidence of thalassemia major was
started under the auspices of the Regional Health Administration in 1995 in the city of …

Molecular characterization of β-thalassemia in the Dohuk region of Iraq

NAS Al-Allawi, JMS Jubrael, M Hughson - Hemoglobin, 2006 - Taylor & Francis
β-Thalassemia (thal) is an important health problem in the Dohuk region of northern Iraq
because of its high carrier rate and the frequency of consanguineous marriages. Thus, the …