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The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
The intracellular and extracellular microenvironment of tumor site: the trigger of stimuli‐responsive drug delivery systems
The tumor microenvironment (TME), including intracellular and extracellular
microenvironment, contains many biochemical indicators (such as acidity/alkalinity, oxygen …
microenvironment, contains many biochemical indicators (such as acidity/alkalinity, oxygen …
[HTML][HTML] Biomedical applications of MnO2 nanomaterials as nanozyme-based theranostics
Abstract Manganese dioxide (MnO 2) nanoenzymes/nanozymes (MnO 2-NEs) are 1–100
nm nanomaterials that mimic catalytic, oxidative, peroxidase, and superoxide dismutase …
nm nanomaterials that mimic catalytic, oxidative, peroxidase, and superoxide dismutase …
Recent progress in stimuli-responsive polymeric micelles for targeted delivery of functional nanoparticles
Stimuli-responsive polymeric micelles have emerged as a revolutionary approach for
enhancing the in vivo stability, biocompatibility, and targeted delivery of functional …
enhancing the in vivo stability, biocompatibility, and targeted delivery of functional …
Photoswitchable molecules in long-wavelength light-responsive drug delivery: from molecular design to applications
Stimuli-responsive nanocarriers can release their bioactive cargo “on demand”, potentially
improving the selectivity, specificity, and efficacy of therapeutic drugs. Light of wavelengths …
improving the selectivity, specificity, and efficacy of therapeutic drugs. Light of wavelengths …
Development of hypoxia-activated PROTAC exerting a more potent effect in tumor hypoxia than in normoxia
W Cheng, S Li, X Wen, S Han, S Wang, H Wei… - Chemical …, 2021 - pubs.rsc.org
Hypoxia is a hallmark of many solid tumors, and it causes the overexpression of a variety of
proteins including the epidermal growth factor receptor (EGFR). Many antitumor prodrugs …
proteins including the epidermal growth factor receptor (EGFR). Many antitumor prodrugs …
[HTML][HTML] Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunity
Cancer remains one of the most formidable challenges in modern medicine, due to its
complex and dynamic nature, which demands innovative therapeutic approaches. One …
complex and dynamic nature, which demands innovative therapeutic approaches. One …
[HTML][HTML] Delivery of therapeutic oligonucleotides in nanoscale
Therapeutic oligonucleotides (TOs) represent one of the most promising drug candidates in
the targeted cancer treatment due to their high specificity and capability of modulating …
the targeted cancer treatment due to their high specificity and capability of modulating …
Recent advances in nanoparticle-based targeted drug-delivery systems against cancer and role of tumor microenvironment
Cancer is one of the major causes of death worldwide. The silent activation of cellular factors
responsible for deviation from normal regulatory pathways leads to the development of …
responsible for deviation from normal regulatory pathways leads to the development of …
Hypoxia-responsive nanoparticles for tumor-targeted drug delivery
Hypoxia is a negative prognostic indicator of solid tumors. Increasing evidence indicates that
the intratumoral hypoxic microenvironment is strongly related to enhanced tumor …
the intratumoral hypoxic microenvironment is strongly related to enhanced tumor …