Organoids are 3D cell culture systems that mimic some of the structural and functional
characteristics of an organ. Organoid cultures provide the opportunity to study organ-level …

Collagen is the main structural protein of most hard and soft tissues in animals and the
human body, which plays an important role in maintaining the biological and structural …

Sensing the mechanical properties of the substrates or the matrix by the cells and the
tissues, the subsequent downstream responses at the cellular, nuclear and epigenetic levels …

Biological materials found in living organisms, many of which are proteins, feature a
complex hierarchical organization. Type I collagen, a fibrous structural protein ubiquitous in …

Simple Summary For the research and development of drug discovery, it is of prime
importance to construct the three-dimensional (3D) tissue models in vitro. To this end, the …

Bioinks play a central role in 3D-bioprinting by providing the supporting environment within
which encapsulated cells can endure the stresses encountered during the digitally driven …

Engineering synthetic scaffolds to repair and regenerate ruptured native tendon and
ligament (T/L) tissues is a significant engineering challenge due to the need to satisfy both …

Stem cell regenerative potential owing to the capacity to self-renew as well as differentiate
into other cell types is a promising avenue in regenerative medicine. Stem cell niche not …

Non-woven nanofibrous scaffolds have been developed for tendon graft application by
using electrospinning strategies. However, electrospun nanofibrous scaffolds face some …

Tendon and ligament tissue regeneration and replacement are complex since scaffolds
need to guarantee an adequate hierarchical structured morphology, and non-linear …