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Mode-of-action of antimicrobial peptides: membrane disruption vs. intracellular mechanisms
Antimicrobial peptides are an attractive alternative to traditional antibiotics, due to their
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …
Non-membrane permeabilizing modes of action of antimicrobial peptides on bacteria
Antimicrobial peptides (AMPs) are a large class of innate immunity effectors with a
remarkable capacity to inactivate microorganisms. Their ability to kill bacteria by …
remarkable capacity to inactivate microorganisms. Their ability to kill bacteria by …
Alteration of Zeta potential and membrane permeability in bacteria: a study with cationic agents
In the present study, we have tried to establish the correlation between changes in Zeta
potential with that of cell surface permeability using bacteria (Escherichia coli and …
potential with that of cell surface permeability using bacteria (Escherichia coli and …
Contribution of amphipathicity and hydrophobicity to the antimicrobial activity and cytotoxicity of β-hairpin peptides
Bacteria have acquired extensive resistance mechanisms to protect themselves against
antibiotic action. Today the bacterial membrane has become one of the “final frontiers” in the …
antibiotic action. Today the bacterial membrane has become one of the “final frontiers” in the …
Discovery, structure, function, and applications of cyclotides: circular proteins from plants
Cyclotides are plant-derived cyclic peptides that have a head-to-tail cyclic backbone and
three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants …
three conserved disulphide bonds that form a cyclic cystine knot motif. They occur in plants …
The prototypic cyclotide kalata B1 has a unique mechanism of entering cells
Cyclotides combine the stability of disulfide-rich peptides with the intracellular accessibility
of cell-penetrating peptides, giving them outstanding potential as drug scaffolds with an …
of cell-penetrating peptides, giving them outstanding potential as drug scaffolds with an …
Bio‐inspired synthesis of sulphur nanoparticles using leaf extract of four medicinal plants with special reference to their antibacterial activity
We report new, eco‐friendly and green method for the synthesis of sulphur nanoparticles
using sodium polysulphide in the presence of leaf extracts of four different medicinal plants …
using sodium polysulphide in the presence of leaf extracts of four different medicinal plants …
[HTML][HTML] Apoptotic human neutrophil peptide-1 anti-tumor activity revealed by cellular biomechanics
Cancer remains a major cause of morbidity and mortality worldwide. Although progress has
been made regarding chemotherapeutic agents, new therapies that combine increased …
been made regarding chemotherapeutic agents, new therapies that combine increased …
[HTML][HTML] Structure, function, and biosynthetic origin of octapeptin antibiotics active against extensively drug-resistant Gram-negative bacteria
Resistance to the last-resort antibiotic colistin is now widespread and new therapeutics are
urgently required. We report the first in toto chemical synthesis and pre-clinical evaluation of …
urgently required. We report the first in toto chemical synthesis and pre-clinical evaluation of …
Enhancing the Intrinsic Antiplasmodial Activity and Improving the Stability and Selectivity of a Tunable Peptide Scaffold Derived from Human Platelet Factor 4
The control of malaria, a disease caused by Plasmodium parasites that kills over half a
million people every year, is threatened by the continual emergence and spread of drug …
million people every year, is threatened by the continual emergence and spread of drug …