The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …

Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as
such are vitally important for humoral immunity. The study of GC biology has undergone a …

Plasma cells (PC) are found in the CNS of multiple sclerosis (MS) patients, yet their source
and role in MS remains unclear. We find that some PC in the CNS of mice with experimental …

Higher-or lower-affinity germinal center (GC) B cells are directed either to plasma cell or GC
recycling, respectively; however, how commitment to the plasma cell fate takes place is …

In this study, we show that evolutionarily conserved chromosome loop anchors bound by
CCCTC-binding factor (CTCF) and cohesin are vulnerable to DNA double strand breaks …

During unresolved infections, some viruses escape immunological control and establish a
persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which …

It is now well accepted that plasma cells can become long-lived (memory) plasma cells and
secrete antibodies for months, years or a lifetime. However, the mechanisms involved in this …

Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry,
where they provide immediate protection against reinfection. To enforce tissue retention …

Plasma cell differentiation requires silencing of B cell transcription, while it establishes
antibody-secretory function and long-term survival. The transcription factors Blimp-1 and …

Ameliorating T cell exhaustion and enhancing effector function are promising strategies for
the improvement of immunotherapies. Here, we show that the HPK1-NFκB-Blimp1 axis …