Maintaining the structure of protein and peptide drugs has become one of the most important
goals of scientists in recent decades. Cold and thermal denaturation conditions …

Insulin and its homologous are the most utilized protein drugs due to their role in diabetic
patients' treatment. Insulin forms amyloid-like fibrils in vivo at the injection site. Therefore, the …

Insulin aggregation poses a significant problem in pharmacology and medicine as it occurs
during prolonged storage of the hormone and in vivo at insulin injection sites. We have …

Repairing multiphasic defects is cumbersome. This study presents new soft and hard
scaffold designs aimed at facilitating the regeneration of multiphasic defects by enhancing …

Even after the centenary celebration of insulin discovery, there prevail challenges
concerning insulin aggregation, not only after repeated administration but also during …

Bioconjugation is a powerful protein modification strategy to improve protein properties.
Herein, we report mechano-bioconjugation as a novel approach to empower fusion protein …

Given the significance of protein aggregation in proteinopathies and the development of
therapeutic protein pharmaceuticals, revamped interest in assessing and modelling the …

Recombinant insulin is a life-saving therapeutic for millions of patients affected by diabetes
mellitus. Standard mutagenesis has led to insulin variants with improved control of blood …

Pyrrolidones have aroused enormous interest as a useful structural moiety in drug
discovery; however, not only does their syntheses suffer from low selectivity and yield, but …

“Core/shell” nanocomposites based on magnetic magnetite (Fe3O4) and redox-active
cerium dioxide (CeO2) nanoparticles (NPs) are promising in the field of biomedical interests …