Regulatory T cells in cancer immunotherapy
FOXP3-expressing regulatory T (Treg) cells, which suppress aberrant immune response
against self-antigens, also suppress anti-tumor immune response. Infiltration of a large …
against self-antigens, also suppress anti-tumor immune response. Infiltration of a large …
Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis
B Shang, Y Liu, S Jiang, Y Liu - Scientific reports, 2015 - nature.com
The prognostic value of FoxP3+ regulatory T cells (Tregs) in cancer remains controversial.
We did a meta-analysis to assess the prognostic effect of FoxP3+ Treg across different types …
We did a meta-analysis to assess the prognostic effect of FoxP3+ Treg across different types …
[HTML][HTML] Tumor-associated macrophages and survival in classic Hodgkin's lymphoma
Background Despite advances in treatments for Hodgkin's lymphoma, about 20% of patients
still die from progressive disease. Current prognostic models predict the outcome of …
still die from progressive disease. Current prognostic models predict the outcome of …
Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse
Purpose To assess the clinical significance of tumor-infiltrating FOXP3-positive regulatory T
cells (TR) in breast cancer patients with long-term follow-up. Patients and Methods FOXP3 …
cells (TR) in breast cancer patients with long-term follow-up. Patients and Methods FOXP3 …
Regulatory T cells in cancer immunotherapy
Highlights•The vital role of FOXP3+ CD25+ CD4+ regulatory T (Treg) cells in tumor immunity
is described.•FOXP3+ CD25+ CD4+ Treg cells are abundantly present in tumor tissues and …
is described.•FOXP3+ CD25+ CD4+ Treg cells are abundantly present in tumor tissues and …
Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
Q Gao, SJ Qiu, J Fan, J Zhou, XY Wang… - Journal of clinical …, 2007 - ascopubs.org
Purpose To investigate the prognostic value of tumor-infiltrating lymphocytes (TILs),
especially regulatory T cells (Tregs), in hepatocellular carcinoma (HCC) patients after …
especially regulatory T cells (Tregs), in hepatocellular carcinoma (HCC) patients after …
The tumour microenvironment in B cell lymphomas
B cell lymphomas are cancers that arise from cells that depend on numerous highly
orchestrated interactions with immune and stromal cells in the course of normal …
orchestrated interactions with immune and stromal cells in the course of normal …
Prevalence of FOXP3+ Regulatory T Cells Increases During the Progression of Pancreatic Ductal Adenocarcinoma and Its Premalignant Lesions
N Hiraoka, K Onozato, T Kosuge, S Hirohashi - Clinical cancer research, 2006 - AACR
Purpose: Antitumor immune response changes drastically during the progression of
cancers. Established cancers often escape from the host immune system, although specific …
cancers. Established cancers often escape from the host immune system, although specific …
Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma
Immunomodulatory drugs (IMiDs) are thalidomide analogues, which possess pleiotropic anti-
myeloma properties including immune-modulation, anti-angiogenic, anti-inflammatory and …
myeloma properties including immune-modulation, anti-angiogenic, anti-inflammatory and …
Regulatory T cells in cancer
Increasing evidence supports the existence of elevated numbers of regulatory T cells (Treg
cells) in solid tumors and hematologic malignancies. Whereas the biology of CD4+ CD25+ …
cells) in solid tumors and hematologic malignancies. Whereas the biology of CD4+ CD25+ …