Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications
Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …
play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid …
Electrochemical transformations catalyzed by cytochrome P450s and peroxidases
Cytochrome P450s (Cyt P450s) and peroxidases are enzymes featuring iron heme cofactors
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …
that have wide applicability as biocatalysts in chemical syntheses. Cyt P450s are a family of …
Strategies for stabilization of enzymes in organic solvents
V Stepankova, S Bidmanova, T Koudelakova… - Acs …, 2013 - ACS Publications
One of the major barriers to the use of enzymes in industrial biotechnology is their
insufficient stability under processing conditions. The use of organic solvent systems instead …
insufficient stability under processing conditions. The use of organic solvent systems instead …
P450 BM3 (CYP102A1): connecting the dots
CJC Whitehouse, SG Bell, LL Wong - Chemical Society Reviews, 2012 - pubs.rsc.org
P450BM3 (CYP102A1), a fatty acid hydroxylase from Bacillus megaterium, has been
extensively studied over a period of almost forty years. The enzyme has been redesigned to …
extensively studied over a period of almost forty years. The enzyme has been redesigned to …
Cytochromes P450 as versatile biocatalysts
R Bernhardt - Journal of biotechnology, 2006 - Elsevier
Cytochromes P450 are ubiquitously distributed enzymes, which were discovered about 50
years ago and which possess high complexity and display a broad field of activity. They are …
years ago and which possess high complexity and display a broad field of activity. They are …
Enzymatic Hydroxylations of sp3-Carbons
Enzymatic hydroxylation of activated and nonactivated sp3-carbons attracts keen interest
from the chemistry community as it is one of the most challenging tasks in organic synthesis …
from the chemistry community as it is one of the most challenging tasks in organic synthesis …
Hemoproteins reconstituted with artificial metal complexes as biohybrid catalysts
Conspectus In nature, heme cofactor-containing proteins participate not only in electron
transfer and O2 storage and transport but also in biosynthesis and degradation. The …
transfer and O2 storage and transport but also in biosynthesis and degradation. The …
Cytochromes P450 as useful biocatalysts: addressing the limitations
Cytochrome P450 monooxygenases (P450s or CYPs) are a unique family of enzymes which
are capable of catalysing the regio-and stereospecific oxidation of non-functionalised …
are capable of catalysing the regio-and stereospecific oxidation of non-functionalised …
Cytochrome P450 monooxygenases: perspectives for synthetic application
VB Urlacher, S Eiben - Trends in biotechnology, 2006 - cell.com
Cytochrome P450 monooxygenases are versatile biocatalysts that introduce oxygen into a
vast range of molecules. These enzymes catalyze diverse reactions in a regio-and …
vast range of molecules. These enzymes catalyze diverse reactions in a regio-and …
Variations on a (t) heme—novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily
Covering: up to the end of 2006The catalytic potential of the P450s in organic
biotransformations is the subject of this review—with emphasis on the breadth of P450 redox …
biotransformations is the subject of this review—with emphasis on the breadth of P450 redox …