Background and Purpose—This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …

Abstract The 'Vascular Depression'hypothesis posits that cerebrovascular disease may
predispose, precipitate or perpetuate some geriatric depressive syndromes. This hypothesis …

Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen
on neuroimaging include recent small subcortical infarcts, lacunes, white matter …

Lesions of the cerebral white matter (WM) result in focal neurobehavioral syndromes,
neuropsychiatric phenomena, and dementia. The cerebral WM contains fiber pathways that …

Most strokes are covert and observed incidentally on brain scans, but their presence
increases risk of overt stroke and dementia. Amyloid angiopathy, associated with Alzheimer …

Objectives: MRI white matter hyperintensity (WMH) volume is associated with cognitive
impairment. We hypothesized that specific loci of WMH would correlate with cognition even …

Rationale As the population of the world ages, age-related cognitive decline is becoming an
ever-increasing problem. However, the changes in brain structure that accompany normal …

White matter hyperintensities (WMHs), mainly caused by cerebrovascular injury, may lead to
cognitive impairment. In order to identify whether the volume of WMHs is associated with …

Few studies have investigated in vivo changes of the cholinergic basal forebrain in
Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI), an at risk stage of …

Objective: Cognitive impairment and neurocirculatory abnormalities such as orthostatic
hypotension (OH), supine hypertension (SH), and failure to decrease blood pressure at night …