Homeobox genes (HOX) are a large family of transcription factors that direct the formation of
many body structures during early embryonic development. There are 39 genes in the …

Neurons exhibit a limited ability of repair. Given that mechanical forces affect neuronal
outgrowth, it is important to investigate whether mechanosensitive ion channels may …

Transcription factors establish the tremendous diversity of cell types in the nervous system
by regulating the expression of genes that give a cell its morphological and functional …

Neurogenesis in Drosophila occurs in two phases, embryonic and post-embryonic, in which
the same set of neuroblasts give rise to the distinct larval and adult nervous systems …

The nuclear envelope protein lamin A is encoded by the lamin A/C (LMNA) gene, which can
contain missense mutations that cause Emery-Dreifuss muscular dystrophy (EDMD)(p …

Atr is a serine/threonine kinase, known to sense single-stranded DNA breaks and activate
the DNA damage checkpoint by phosphorylating Chek1, which inhibits Cdc25, causing cell …

During development, neurons switch among growth states, such as initial axon outgrowth,
axon pruning, and regrowth. By studying the stereotypic remodeling of the Drosophila …

Mechanisms that coordinate growth during development are essential for producing animals
with proper organ proportion. Here we describe a pathway through which tissues …

Homozygous Mnx1 mutation causes permanent neonatal diabetes in humans, but via
unknown mechanisms. Our systematic and longitudinal analysis of Mnx1 function during …

Fox genes represent an evolutionary old class of transcription factor encoding genes that
evolved in the last common ancestor of fungi and animals. They represent key-components …