Conoid extrusion regulates glideosome assembly to control motility and invasion in Apicomplexa
N Dos Santos Pacheco, L Brusini, R Haase… - Nature …, 2022 - nature.com
Members of Apicomplexa are defined by apical cytoskeletal structures and secretory
organelles, tailored for motility, invasion and egress. Gliding is powered by actomyosin …
organelles, tailored for motility, invasion and egress. Gliding is powered by actomyosin …
The initiation and early development of apical–basal polarity in Toxoplasma gondii
The body plan of the human parasite Toxoplasma gondii has a well-defined polarity. The
minus ends of the 22 cortical microtubules are anchored to the apical polar ring, which is a …
minus ends of the 22 cortical microtubules are anchored to the apical polar ring, which is a …
Egress Regulatory Factors: How Toxoplasma Exits from Infected Cells?
Y Diao, Y Yao, S El-Ashram, M Bian - Pathogens, 2023 - mdpi.com
Toxoplasma gondii is an obligatory intracellular protozoan in the family Apicomplexa. It
infects almost one-third of the world's population and causes toxoplasmosis, a prevalent …
infects almost one-third of the world's population and causes toxoplasmosis, a prevalent …
[HTML][HTML] Nanoscale imaging of the conoid and functional dissection of its dynamics in Apicomplexa
Highlights•Importance of ERK7 in the biogenesis, stability, and turnover of the
conoid.•Nanoscale imaging of the conoid by cryo-electron tomography and expansion …
conoid.•Nanoscale imaging of the conoid by cryo-electron tomography and expansion …
The cortical microtubules of Toxoplasma gondii underlie the helicity of parasite movement
Motility is essential for apicomplexan parasites to infect their hosts. In a three-dimensional
(3D) environment, the apicomplexan parasite Toxoplasma gondii moves along a helical …
(3D) environment, the apicomplexan parasite Toxoplasma gondii moves along a helical …
A circular zone of attachment to the extracellular matrix provides directionality to the motility of Toxoplasma gondii in 3D
Toxoplasma gondii is a protozoan parasite that infects 30–40% of the world's population.
Infections are typically subclinical but can be severe and, in some cases, life threatening …
Infections are typically subclinical but can be severe and, in some cases, life threatening …
The initiation and early development of the tubulin-containing cytoskeleton in the human parasite Toxoplasma gondii
The tubulin-containing cytoskeleton of the human parasite Toxoplasma gondii includes
several distinct structures: the conoid, formed of 14 ribbon-like tubulin polymers, and the …
several distinct structures: the conoid, formed of 14 ribbon-like tubulin polymers, and the …
Cryogenic electron tomography reveals novel structures in the apical complex of Plasmodium falciparum
Intracellular infectious agents, like the malaria parasite, Plasmodium falciparum, face the
daunting challenge of how to invade a host cell. This problem may be even harder when the …
daunting challenge of how to invade a host cell. This problem may be even harder when the …
Conoid extrusion serves as gatekeeper for entry of glideosome components into the pellicular space to control motility and invasion in Apicomplexa
N Dos Santos Pacheco, L Brusini, R Haase, N Tosetti… - BioRxiv, 2022 - biorxiv.org
Members of the Apicomplexa are defined by apical cytoskeletal structures and secretory or-
ganelles, tailored for motility and invasion. Gliding is powered by actomyosin-dependent …
ganelles, tailored for motility and invasion. Gliding is powered by actomyosin-dependent …
[HTML][HTML] A Comprehensive Review of Toxoplasmosis: Serious Threat to Human Health
AR Khairullah, SC Kurniawan… - The Open Public …, 2024 - openpublichealthjournal.com
Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii. Despite infecting a
major fraction of the global population, T. gondii rarely results in clinically significant …
major fraction of the global population, T. gondii rarely results in clinically significant …