The assembly of the five oxidative phosphorylation system (OXPHOS) complexes in the
inner mitochondrial membrane is an intricate process. The human enzymes comprise core …

Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed,
and are present in the nucleus, cytosol, and mitochondria. Depending on the cellular …

Members of the Atg8 family of proteins are conjugated to autophagosomal membranes,
where they have been proposed to drive autophagosome formation and selective …

Complex I (NADH: ubiquinone oxidoreductase) is the first enzyme of the mitochondrial
respiratory chain and is composed of 45 subunits in humans, making it one of the largest …

Mitochondrial complex I (also known as NADH: ubiquinone oxidoreductase) contributes to
cellular energy production by transferring electrons from NADH to ubiquinone coupled to …

Cargo sequestration is a fundamental step of selective autophagy in which cells generate a
double-membrane structure termed an" autophagosome" on the surface of cargoes. NDP52 …

PINK1 is a mitochondrial kinase mutated in some familial cases of Parkinson's disease. It
has been found to work in the same pathway as the E3 ligase Parkin in the maintenance of …

Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic
pH is associated with aging and neurodegenerative diseases. However, the mechanisms …

Current models of selective autophagy dictate that autophagy receptors, including
Optineurin and NDP52, link cargo to autophagosomal membranes. This is thought to occur …

Protein ubiquitination is a multi-functional post-translational modification that affects all
cellular processes. Its versatility arises from architecturally complex polyubiquitin chains, in …