CD4+ T cells contribute to neurodegeneration in Lewy body dementia
Recent studies indicate that the adaptive immune system plays a role in Lewy body
dementia (LBD). However, the mechanism regulating T cell brain homing in LBD is …
dementia (LBD). However, the mechanism regulating T cell brain homing in LBD is …
High-dimensional investigation of the cerebrospinal fluid to explore and monitor CNS immune responses
The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …
Intestinal fungi and systemic autoimmune diseases
H Wang, H Wu, KD Li, YY Wang, RG Huang, YJ Du… - Autoimmunity …, 2023 - Elsevier
Nearly 20 years of studies have shown that fungi and the human immune system (non-
specific immunity and specific immunity) and bacterial––fungal interactions maintain a …
specific immunity and specific immunity) and bacterial––fungal interactions maintain a …
Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment
Cerebrospinal fluid (CSF) contains a tightly regulated immune system. However, knowledge
is lacking about how CSF immunity is altered with aging or neurodegenerative disease …
is lacking about how CSF immunity is altered with aging or neurodegenerative disease …
Cryopreservation of cerebrospinal fluid cells preserves the transcriptional landscape for single-cell analysis
Cerebrospinal fluid (CSF) matrix biomarkers have become increasingly valuable surrogate
markers of neuropsychiatric diseases in research and clinical practice. In contrast, CSF cells …
markers of neuropsychiatric diseases in research and clinical practice. In contrast, CSF cells …
Role and relevance of cerebrospinal fluid cells in diagnostics and research: state-of-the-art and underutilized opportunities
F Otto, C Harrer, G Pilz, P Wipfler, A Harrer - Diagnostics, 2021 - mdpi.com
Cerebrospinal fluid (CSF) has recently experienced a revival in diagnostics and research.
However, little progress has been made regarding CSF cell analysis. For almost a century …
However, little progress has been made regarding CSF cell analysis. For almost a century …
CNS-associated T-lymphocytes in a mouse model of Hereditary Spastic Paraplegia type 11 (SPG11) are therapeutic targets for established immunomodulators
Pharmacological targeting of neuroinflammation in distinct models of genetically mediated
disorders of the central nervous system (CNS) has been shown to attenuate disease …
disorders of the central nervous system (CNS) has been shown to attenuate disease …
Emerging single-cell approaches to understand HIV in the central nervous system
MJ Corley, SF Farhadian - Current HIV/AIDS Reports, 2022 - Springer
Abstract Purpose of Review This review highlights emerging single-cell sequencing
methods relevant to translational studies of HIV in the central nervous system (CNS) …
methods relevant to translational studies of HIV in the central nervous system (CNS) …
[HTML][HTML] Stabilization of leukocytes from cerebrospinal fluid for central immunophenotypic evaluation in multicenter clinical trials
I Mexhitaj, N Lim, JI Fernandez-Velasco… - Journal of …, 2022 - Elsevier
Abstract Analysis of cerebrospinal fluid (CSF) represents a valuable window into the
pathogenesis of neuroinflammatory diseases, such as multiple sclerosis (MS). However …
pathogenesis of neuroinflammatory diseases, such as multiple sclerosis (MS). However …
Protocol for the Tallaght University Hospital Institute for Memory and Cognition-Biobank for Research in Ageing and Neurodegeneration
Introduction Alzheimer's disease and other dementias affect> 50 million individuals globally
and are characterised by broad clinical and biological heterogeneity. Cohort and biobank …
and are characterised by broad clinical and biological heterogeneity. Cohort and biobank …