Opioids are effective analgesics, but they can have harmful adverse effects, such as
addiction and potentially fatal respiratory depression. Naloxone is currently the only …

This paper is the 28th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning over a quarter-century of research. It …

Visceral pain is experienced by 40% of the population, and 28% of cancer patients suffer
from pain arising from intra‐abdominal metastasis or from treatment. Neuroanatomy of …

We have recently reported that repeated systemic treatments of extract from Corydalis
yanhusuo alleviate neuropathic pain and levo-tetrahydropalmatine (l-THP) is one of active …

Cannabinoid and opioid agonists can display overlap** behavioral effects and the
combination of these agonists is known to produce enhanced antinociception in several …

Irritable bowel syndrome (IBS) is a complex disorder that is characterized by abdominal pain
and altered bowel habit, and often associates with other gastrointestinal symptoms such as …

Bidens pilosa is an Asteraceae widely used in traditional medicine for the treatment of
various ailments including pain and inflammation. The present work was undertaken to …

The development of combination therapy is a coherent approach in severe pain treatment.
The present study investigated the antinociceptive effect of pregabalin alone and in …

Despite a significant decrease in the number of prescriptions for opioids, the opioid crisis
continues, fueled in large part by the availability of the phenylpiperidine mu opioid receptor …

Cancer pain may be the consequence of physical nerve compression by a growing tumor.
We employed a murine model to study whether gabapentin was able to regulate tumor …