[HTML][HTML] Ultra-low dose aerosol infection of mice with Mycobacterium tuberculosis more closely models human tuberculosis

CR Plumlee, FJ Duffy, BH Gern, JL Delahaye… - Cell host & …, 2021 - cell.com
Tuberculosis (TB) is a heterogeneous disease manifesting in a subset of individuals infected
with aerosolized Mycobacterium tuberculosis (Mtb). Unlike human TB, murine infection …

Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity

Z Zhu, D Surujon, JC Ortiz-Marquez, W Huo… - Nature …, 2020 - nature.com
Current approaches explore bacterial genes that change transcriptionally upon stress
exposure as diagnostics to predict antibiotic sensitivity. However, transcriptional changes …

Assessing vaccine-mediated protection in an ultra-low dose Mycobacterium tuberculosis murine model

CR Plumlee, HW Barrett, DE Shao, KA Lien… - Plos …, 2023 - journals.plos.org
Despite widespread immunization with Bacille-Calmette-Guérin (BCG), the only currently
licensed tuberculosis (TB) vaccine, TB remains a leading cause of mortality globally. There …

Distinct protective roles of CD4 and CD8 T cells in vaccine-mediated immunity against Mycobacterium tuberculosis

H Barrett - 2024 - search.proquest.com
Despite widespread vaccination with Bacille Calmette-Guerin (BCG) globally, tuberculosis
(TB) remains a major global health concern. A new vaccine is urgently needed, but our …