Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …

Immunoengineering applies quantitative and materials-based approaches for the
investigation of the immune system and for the development of therapeutic solutions for …

Bone metastasis primarily occurs when breast, prostate, or lung cancers disseminate
tumoral cells into bone tissue, leading to a range of complications in skeletal tissues and, in …

To investigate B-cell differentiation and maturation occurring in the germinal center (GC)
using in vitro culture systems, key factors and interactions of the GC reaction need to be …

In vitro cell cultures are fundamental and necessary tools in cancer research and
personalized drug discovery. Currently, most cells are cultured using two-dimensional (2D) …

Emerging evidence indicates that cancer cells can mimic characteristics of embryonic
development, promoting their development and progression. Cancer cells share features …

Despite the wide variety of existing therapies, multiple myeloma (MM) remains a disease
with dismal prognosis. Choosing the right treatment for each patient remains one of the …

We engineered an in vitro model of bioartificial 3D bone organoid consistent with an
anatomical and vascular microenvironment common to mammalian flat and short bones. To …

Simple Summary The ability of cancer cells to evade the immunological response of the host
has been recognized as one of the hallmarks of cancer. Better understanding of this …

Bone marrow (BM) is an organ responsible for crucial processes in living organs, eg,
hematopoiesis. In recent years, Organ-on-a-Chip (OoC) devices have been used to satisfy …