Type 2 diabetes and major depressive disorder (MDD) are the leading causes of disability
worldwide and have a high comorbidity rate with fatal outcomes. Despite the long …

As the obesity epidemic, diabetes mellitus type 2, and associated comorbidities show no
signs of abating, large efforts have been put into a better understanding of the homeostatic …

Central dopaminergic mechanisms are involved in the motivational aspects of eating and
food choices. This review focuses on human and animal data investigating the importance of …

The hormones insulin and leptin have been demonstrated to act in the central nervous
system (CNS) as regulators of energy homeostasis at medial hypothalamic sites. In a …

Overconsumption of dietary fat is increasingly linked with motivational and emotional
impairments. Human and animal studies demonstrate associations between obesity and …

The hormones insulin and leptin have been proposed to act in the central nervous system
(CNS) as adiposity signals as part of a theoretical negative feedback loop that senses the …

The magnitude and duration of dopamine (DA) signaling is defined by the amount of
vesicular release, DA receptor sensitivity, and the efficiency of DA clearance, which is …

The tendency to engage in or maintain feeding behaviour is potently influenced by the
rewarding properties of food. Affective and goal-directed behavioural responses for food …

Data from our laboratory and others have demonstrated an effect of the candidate adiposity
signals insulin and leptin to decrease brain reward function, as assessed by lateral …

Chronic food restriction (FR) increases behavioral sensitivity to drugs of abuse in animal
models and is associated with binge eating, which shares comorbidity with drug abuse, in …