Diabetes is a prevalent chronic disease that traditionally requires severe reliance on
medication for treatment. Oral medication and exogenous insulin can only temporarily …

Islet transplantation represents an effective treatment for patients with type 1 diabetes
mellitus (T1DM) and severe hypoglycaemia unawareness, capable of circumventing …

Antigen-specific tolerance is a key goal of experimental immunotherapies for autoimmune
disease and allograft rejection. This outcome could selectively inhibit detrimental …

Hybridizing biological cells with man‐made sensors enable the detection of a wide range of
weak physiological responses with high specificity. The anterior chamber of the eye (ACE) is …

Islets transplantation is a promising treatment for type 1 diabetes mellitus. However, severe
host immune rejection and poor oxygen/nutrients supply due to the lack of surrounding …

A global online survey was administered to 69 islet transplantation programs, covering 84
centers and 5 networks. The survey addressed questions on program organization and …

Insufficient revascularization of pancreatic islets is one of the major obstacles impairing the
success of islet transplantation. To overcome this problem, we introduce in the present study …

Intrahepatic islet transplantation is a promising β-cell replacement strategy for the treatment
of type 1 diabetes. Instant blood-mediated inflammatory reactions, acute inflammatory storm …

Optogenetic techniques permit non-invasive, spatiotemporal, and reversible modulation of
cellular activities. Here, we report a novel optogenetic regulatory system for insulin secretion …

Beta cell replacement has emerged as an attractive therapeutic alternative to traditional
exogenous insulin administration for management of type 1 diabetes (T1D). Beta cells …