In addition to the burden of a life-threatening diagnosis, cancer patients are struggling with
adverse side-effects from cancer treatment. Chemotherapy has been linked to an array of …

Central nervous system (CNS) metastasis will develop in 50% of small cell lung cancer
(SCLC) patients throughout disease course. Development of CNS metastasis poses a …

Abstract Background & Objectives: Radiotherapy is standard treatment for patients with brain
metastases (BMs), although it may lead to radiation-induced cognitive impairment. This …

Small cell lung cancer (SCLC) is an aggressive form of lung cancer associated with an
increased risk of devel** brain metastases (BM), which are a significant cause of morbidity …

Prophylactic cranial irradiation (PCI) for SCLC offers a consistent reduction in the incidence
of brain metastases at the cost of measurable toxicity to neurocognitive function and quality …

Increasing evidence indicates that radiation-induced injury to the hippocampus may play a
critical role in neurocognitive dysfunction in patients with nasopharyngeal carcinoma (NPC) …

Purpose We used quantitative magnetic resonance imaging to prospectively analyze the
association between microstructural damage to memory-associated structures within the …

Background The landscape of brain metastases radiotherapy is evolving, with a shift away
from whole-brain radiotherapy (WBRT) toward targeted stereotactic approaches aimed at …

Over 10% of small-cell lung cancer (SCLC) patients have brain metastases (BM) at initial
diagnosis; more than 50% will develop BM within 2 years. BM are detected in up to 80% of …

Background and purpose The aim of this prospective study is to evaluate post-whole brain
radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) …