Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

Chronic calorie restriction (CR) improves cardiovascular function and several other
physiological markers of healthspan. However, CR is impractical in non-obese older …

Dietary restriction (DR) is defined as a moderate reduction in food intake while avoiding
malnutrition. The beneficial effects of DR are being increasingly acknowledged in aging and …

Lung adenocarcinomas are more common in non-smoking males and females. In this study,
we investigated the function of long non-coding RNA RMRP in lung adenocarcinoma and …

Calorie restriction (CR) extends lifespan and healthspan in diverse species. Comparing ad
libitum-and CR-fed mice is challenging due to their significantly different feeding patterns …

Background: Glioblastoma (GBM) represents the most aggressive glioma with high invasive
potential. Recent studies proved the involvement of epithelial-mesenchymal transition (EMT) …

Caloric restriction can decrease the incidence of metabolic diseases, such as obesity and
Type 2 diabetes mellitus. The mechanisms underlying the benefits of caloric restriction …

Decreased sperm quality causing poor pregnancy outcomes in aging males is a common
problem. The aim of this study was to investigate the ameliorative effect of methionine …

The effect of calorie restriction (CR) on the microbiome, fecal metabolome, and colon
transcriptome of adult and old male mice was compared. Life-long CR increased microbial …

Depletion of macrophages is thought to be a therapeutic option for obesity-induced
inflammation and metabolic dysfunction. However, whether the therapeutic effect is a direct …