Phosphoinositides as membrane organizers
Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …
Phosphoinositides: tiny lipids with giant impact on cell regulation
T Balla - Physiological reviews, 2013 - journals.physiology.org
Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
control almost all aspects of a cell's life and death. These lipids gained tremendous research …
PI3K isoforms in cell signalling and vesicle trafficking
B Bilanges, Y Posor, B Vanhaesebroeck - Nature reviews Molecular …, 2019 - nature.com
PI3Ks are a family of lipid kinases that phosphorylate intracellular inositol lipids to regulate
signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided …
signalling and intracellular vesicular traffic. Mammals have eight isoforms of PI3K, divided …
A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin
Q Chai, S Yu, Y Zhong, Z Lu, C Qiu, Y Yu, X Zhang… - Science, 2022 - science.org
The inflammasome-mediated cleavage of gasdermin D (GSDMD) causes pyroptosis and
inflammatory cytokine release to control pathogen infection, but how pathogens evade this …
inflammatory cytokine release to control pathogen infection, but how pathogens evade this …
ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology
AG Manford, CJ Stefan, HL Yuan, JA MacGurn… - Developmental cell, 2012 - cell.com
Endoplasmic reticulum-plasma membrane (ER-PM) junctions are conserved structures
defined as regions of the ER that tightly associate with the plasma membrane. However, little …
defined as regions of the ER that tightly associate with the plasma membrane. However, little …
Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids
Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …
Molecular physiology of TRPV channels: controversies and future challenges
The ability to detect stimuli from the environment plays a pivotal role in our survival. The
molecules that allow the detection of such signals include ion channels, which are proteins …
molecules that allow the detection of such signals include ion channels, which are proteins …
A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi
GRV Hammond, MP Machner, T Balla - Journal of Cell Biology, 2014 - rupress.org
Polyphosphoinositides are an important class of lipid that recruit specific effector proteins to
organelle membranes. One member, phosphatidylinositol 4-phosphate (PtdIns4 P) has …
organelle membranes. One member, phosphatidylinositol 4-phosphate (PtdIns4 P) has …
Phosphoinositides regulate ciliary protein trafficking to modulate hedgehog signaling
Primary cilia interpret vertebrate Hedgehog (Hh) signals. Why cilia are essential for
signaling is unclear. One possibility is that some forms of signaling require a distinct …
signaling is unclear. One possibility is that some forms of signaling require a distinct …
Phosphoinositides regulate ion channels
Phosphoinositides serve as signature motifs for different cellular membranes and often are
required for the function of membrane proteins. Here, we summarize clear evidence …
required for the function of membrane proteins. Here, we summarize clear evidence …