Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and
chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus …

Covering: 1987 to 2013 Natural products and related structures are essential sources of new
pharmaceuticals, because of the immense variety of functionally relevant secondary …

phenix. refine is a program within the PHENIX package that supports crystallographic
structure refinement against experimental data with a wide range of upper resolution limits …

Peroxiredoxins (Prxs), some of nature's dominant peroxidases, use a conserved Cys residue
to reduce peroxides. They are highly expressed in organisms from all kingdoms, and in …

The global pandemic from COVID-19 infection has generated significant public health
concerns, both health-wise and economically. There is no specific pharmacological antiviral …

Protein thiol reactivity generally involves the nucleophilic attack of the thiolate on an
electrophile. A low p K a means higher availability of the thiolate at neutral pH but often a …

Purine biosynthesis requires ten enzymatic transformations to generate inosine
monophosphate. PurF, PurD, PurL, PurM, PurC, and PurB are common to all pathways …

A complete description of the serological response following exposure of humans to
complex pathogens is lacking and approaches suitable for accomplishing this are limited …

Calcium-dependent protein kinases (CDPKs) have pivotal roles in the calcium-signaling
pathway in plants, ciliates and apicomplexan parasites and comprise a calmodulin …

Processes maintaining protein homeostasis in the cell are governed by the activities of
molecular chaperones that mainly assist in the folding of polypeptide chains and by a large …