▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

Neurotrophins are a family of closely related proteins that were identified initially as survival
factors for sensory and sympathetic neurons, and have since been shown to control many …

Neurons are specialized cells with a complex morphology that represent the functional unit
of the nervous system. They are generated in remarkable numbers, particularly in higher …

The neurotrophins are growth factors that play critical roles in the development,
maintenance, survival, and death of the nervous system. The signal transducing systems …

The striatum, a major component of the basal ganglia, performs multiple functions including
control of movement, reward, and addiction. Dysfunction and death of striatal neurons are …

Although the requirement of neurotrophins for the prevention of cell death in the peripheral
nervous system is well established, their physiological involvement in nerve growth is still …

The glial cell line–derived neurotrophic factor (GDNF) ligands (GDNF, Neurturin [NTN], and
Persephin [PSP]) signal through a multicomponent receptor system composed of a high …

Neuromas are a substantial cause of morbidity and reduction in quality of life. This is not
only caused by a disruption in motor and sensory function from the underlying nerve injury …

Different classes of sensory neurons in dorsal root ganglia (DRG) are generated in two
waves: large-diameter trkC+ and trkB+ neurons are born first, followed by small-diameter …

During the development of the nervous system, many different types of neuron are
produced. As well as forming the correct type of neuron, each must also establish precise …