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CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential
CD8 T cells play crucial roles in immune surveillance and defense against infections and
cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire …
cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire …
Stem-like exhausted and memory CD8+ T cells in cancer
T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program
Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic
lymphocytic choriomeningitis virus infection. Here we examine the underlying basis for this …
lymphocytic choriomeningitis virus infection. Here we examine the underlying basis for this …
Human circulating and tissue-resident memory CD8+ T cells
Our current knowledge of human memory CD8+ T cells is derived largely from studies of the
intravascular space. However, emerging data are starting to challenge some of the dogmas …
intravascular space. However, emerging data are starting to challenge some of the dogmas …
[HTML][HTML] Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses
Summary CD4 T follicular helper (TFH) cells support B cells, which are critical for germinal
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …
center (GC) formation, but the importance of TFH-B cell interactions in cancer is unclear. We …
A reservoir of stem-like CD8+ T cells in the tumor-draining lymph node preserves the ongoing antitumor immune response
“Stem-like” TCF1+ CD8+ T (TSL) cells are necessary for long-term maintenance of T cell
responses and the efficacy of immunotherapy, but, as tumors contain signals that should …
responses and the efficacy of immunotherapy, but, as tumors contain signals that should …
Combined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors
TGFβ signaling is associated with non-response to immune checkpoint blockade in patients
with advanced cancers, particularly in the immune-excluded phenotype. While previous …
with advanced cancers, particularly in the immune-excluded phenotype. While previous …
In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue
Improving the efficacy of immune checkpoint therapies will require a better understanding of
how immune cells are recruited and sustained in tumors. Here, we used the …
how immune cells are recruited and sustained in tumors. Here, we used the …
The B7: CD28 family and friends: Unraveling coinhibitory interactions
Immune responses must be tightly regulated to ensure both optimal protective immunity and
tolerance. Costimulatory pathways within the B7: CD28 family provide essential signals for …
tolerance. Costimulatory pathways within the B7: CD28 family provide essential signals for …
Characteristics and anatomic location of PD-1+TCF1+ stem-like CD8 T cells in chronic viral infection and cancer
CD8 T cells play an essential role in antitumor immunity and chronic viral infections. Recent
findings have delineated the differentiation pathway of CD8 T cells in accordance with the …
findings have delineated the differentiation pathway of CD8 T cells in accordance with the …