Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …

Periodontitis are infectious diseases characterized by immune-mediated destruction of
periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key …

Nitric oxide (NO) is a highly reactive molecule, generated through metabolism of L-arginine
by NO synthase (NOS). Abnormal NO levels in mammalian cells are associated with multiple …

It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

Reactive oxygen species (ROS) are recently proposed to be involved in tumor metastasis
which is a complicated processes including epithelial–mesenchymal transition (EMT) …

c-Jun N-terminal kinase (JNK), or stress-activated protein kinase, is an important member of
the mitogen-activated protein kinase superfamily, the members of which are readily …

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen
species-generating enzymes that broadly and specifically regulate redox-sensitive …

Reactive oxygen species (ROS) are formed in mammalian cells as a consequence of
aerobic respiration. Despite multiple conserved redox modulating systems, a given …

Punch biopsies of human skin were obtained 1 day after irradiation with two minimal‐
erythema doses (MED) from either a UVB light source or a Solar Simulator and incubated in …

Physical trauma represents one of the most primitive challenges that threatened survival.
Healing a problem wound requires a multi-faceted comprehensive approach. First and …