The cerebellar cortex
The cerebellar cortex is an important system for relating neural circuits and learning. Its
promise reflects the longstanding idea that it contains simple, repeated circuit modules with …
promise reflects the longstanding idea that it contains simple, repeated circuit modules with …
Climbing fiber multi-innervation of mouse Purkinje dendrites with arborization common to human
Canonically, each Purkinje cell (PC) in the adult cerebellum receives only one climbing fiber
(CF) from the inferior olive. Underlying current theories of cerebellar function is the notion …
(CF) from the inferior olive. Underlying current theories of cerebellar function is the notion …
Intrinsic and synaptic determinants of receptive field plasticity in Purkinje cells of the mouse cerebellum
Non-synaptic (intrinsic) plasticity of membrane excitability contributes to aspects of memory
formation, but it remains unclear whether it merely facilitates synaptic long-term potentiation …
formation, but it remains unclear whether it merely facilitates synaptic long-term potentiation …
Paroxysmal dystonia results from the loss of RIM4 in Purkinje cells
H Kim, N Melliti, E Breithausen, K Michel, SF Colomer… - Brain, 2024 - academic.oup.com
Full-length RIM1 and 2 are key components of the presynaptic active zone that ubiquitously
control excitatory and inhibitory neurotransmitter release. Here, we report that the function of …
control excitatory and inhibitory neurotransmitter release. Here, we report that the function of …
Dendritic coincidence detection in Purkinje neurons of awake mice
Dendritic coincidence detection is fundamental to neuronal processing yet remains largely
unexplored in awake animals. Specifically, the underlying dendritic voltage–calcium …
unexplored in awake animals. Specifically, the underlying dendritic voltage–calcium …
Designing AAV Vectors for Monitoring the Subtle Calcium Fluctuations of Inferior Olive Network in vivo
Adeno-associated viral (AAV) vectors, used as vehicles for gene transfer into the brain, are a
versatile and powerful tool of modern neuroscience that allow identifying specific neuronal …
versatile and powerful tool of modern neuroscience that allow identifying specific neuronal …
Population calcium responses of Purkinje cells in the oculomotor cerebellum driven by nonvisual input
AS Fanning, AM Shakhawat… - Journal of …, 2021 - journals.physiology.org
The climbing fiber input to the cerebellum conveys instructive signals that can induce
synaptic plasticity and learning by triggering complex spikes accompanied by large calcium …
synaptic plasticity and learning by triggering complex spikes accompanied by large calcium …
[HTML][HTML] Sensory over-responsivity and aberrant plasticity in cerebellar cortex in A mouse model of syndromic autism
DH Simmons, SE Busch, HK Titley, G Grasselli… - … Psychiatry Global Open …, 2022 - Elsevier
Background Patients with autism spectrum disorder often show altered responses to sensory
stimuli as well as motor deficits, including an impairment of delay eyeblink conditioning …
stimuli as well as motor deficits, including an impairment of delay eyeblink conditioning …
Stochastic reaction-diffusion modeling of calcium dynamics in 3D dendritic spines of Purkinje cells
VN Friedhoff, G Antunes, M Falcke, FMS de Souza - Biophysical Journal, 2021 - cell.com
Abstract Calcium (Ca 2+) is a second messenger assumed to control changes in synaptic
strength in the form of both long-term depression and long-term potentiation at Purkinje cell …
strength in the form of both long-term depression and long-term potentiation at Purkinje cell …
Multiple climbing fiber innervation of mature Purkinje cells with distinct dendritic subfields
SE Busch, C Hansel - bioRxiv, 2023 - biorxiv.org
In rodents, most Purkinje cells in the adult cerebellum receive one climbing fiber from the
inferior olive. In postnatal competition for innervation of the growing primary dendrite, one …
inferior olive. In postnatal competition for innervation of the growing primary dendrite, one …